Blackburn Lab

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Recent Publications in Peer-Reviewed Scientific Journals

Listerman I, Gazzaniga F, Blackburn EH. An investigation of the effects of the telomerase core protein TERT on Wnt signaling in human breast cancer cells. Mol Cell Biol. 2013 Nov 11. [Epub ahead of print].

Ornish D, Lin J, Chan JM, Epel E, Kemp C, Weidner G, Marlin R, Frenda SJ, Magbanua MJ, Daubenmier J, Estay I, Hills NK, Chainani-Wu N, Carroll PR, Blackburn EH. Effect of comprehensive lifestyle changes on telomerase activity and telomere length in men with biopsy-proven low-risk prostate cancer: 5-year follow-up of a descriptive pilot study. Lancet Oncol. 2013 Oct;14(11):1112-1120. doi: 10.1016/S1470-2045(13)70366-8. Epub 2013 Sep 17.

Zhu Y, Voruganti VS, Lin J, Matsuguchi T, Blackburn E, Best LG, Lee ET, Maccluer JW, Cole SA, Zhao J. QTL mapping of leukocyte telomere length in American Indians: The Strong Heart Family Study. Aging (Albany NY). 2013 Sep 11. PMCID: PMC3808702

Rehkopf DH, Dow WH, Rosero-Bixby L, Lin J, Epel ES, Blackburn EH. Exp Gerontol. Longer leukocyte telomere length in Costa Rica's Nicoya Peninsula: A population-based study. Exp Gerontol. 2013 Nov; 48(11):1266-1273. doi: 10.1016/j.exger.2013.08.005. Epub 2013 Aug 27.

Zhao J, Zhu Y, Lin J, Matsuguchi T, Blackburn E, Zhang Y, Cole SA, Best LG, Lee ET, Howard BV. Short Leukocyte Telomere Length Predicts Risk of Diabetes in American Indians: The Strong Heart Family Study. Diabetes. 2013 Aug 15. [Epub ahead of print]

Puterman E, Epel ES, Lin J, Blackburn EH, Gross JJ, Whooley MA, Cohen BE. Multisystem resiliency moderates the major depression-Telomere length association: Findings from the Heart and Soul Study. Brain Behav Immun. 2013 May 30. doi:pii: S0889-1591(13)00198-0. 10.1016/j.bbi.2013.05.008. [Epub ahead of print] PMCID: in progress

Listerman I, Sun J, Gazzaniga F, Lukas, JJ, Blackburn EH. The major reverse-transcriptase-incompetent splice variant of the human telomerase protein inhibits telomerase activity but protects from apoptosis. Cancer Research . 2013 May 1;73(9):2817-28. doi: 10.1158/0008-5472. CAN-12-3082. Epub 2013 Apr 22.

Entringer S, Epel ES, Lin J, Buss C, Shahbaba B, Blackburn EH, Simhan HN, Wadhwa PD. Maternal psychosocial stress during pregnancy is associated with newborn leukocyte telomere length. Am J Obstet Gynecol. 2013 Feb;208(2):134.e1-7. doi: 10.1016/j.ajog.2012.11.033. Epub 2012 Nov 27.

Bansal N, Whooley MA, Regan M, McCulloch CE, Ix JH, Epel E, Blackburn E, Lin J, Hsu CY. Association between Kidney Function and Telomere Length: The Heart and Soul Study. Am J Nephrol. 2012;36(5):405-11. doi: 10.1159/000343495. Epub 2012 Oct 25. PMCID: PMC3552638

Beery AK, Lin J, Biddle JS, Francis DD, Blackburn EH, Epel ES. Chronic stress elevates telomerase activity in rats. Biol Lett. 2012 Oct 10. [Epub ahead of print]. PMCID: PMC3497144

Kiecolt-Glaser JK, Epel ES, Belury MA, Andridge R, Lin J, Glaser R, Malarkey WB, Hwang BS, Blackburn E. Omega-3 fatty acids, oxidative stress, and leukocyte telomere length: A randomized controlled trial.  Brain Behav Immun. 2012 Sep 23. pii: S0889-1591(12)00431-X. doi: 10.1016/j.bbi.2012.09.004. [Epub ahead of print]. PMCID: PMC3545053

Adler N, Pantell M, O’Donovan A, Blackburn E, Cawthon R, Koster A, Opresko P, Newman A, Harris TB, Epel E. Educational attainment and late life telomere length in the Health, Aging and Body Composition Study. Brain Behav Immun. 2012 Sep 5. pii: S0889-1591(12)00422-9. doi: 10.1016/j.bbi.2012.08.014. [Epub ahead of print]. PMCID: PMC3543785

Needham BL, Fernandez JR, Lin J, Epel ES, Blackburn EH. Socioeconomic status and cell aging in children. Soc Sci Med. 2012 Jun;74(12):1948-51. Epub 2012 Mar 17.

O'Donovan A, Tomiyama AJ, Lin J, Puterman E, Adler NE, Kemeny M, Wolkowitz OM, Blackburn EH, Epel ES. Stress appraisals and cellular aging: A key role for anticipatory threat in the relationship between psychological stress and telomere length. Brain Behav Immun, 2012 May;26(4):573-9. Epub 2012 Jan 24. PMCID: PMC3322317

Lavretsky H, Siddarth P, Nazarian N, St. Cyr N, Khalsa, DS< Lin, J, Blackburn E, Epel ES, and MR Irwin. A pilot study of yogic meditation for family dementia caregivers with depressive symptoms: Effects on mental health, cognition, and telomerase activity. Int J Geriatr Psychiatry. 2012 Mar 11. doi: 10.1002/gps.3790.

Daubenmier, J., Lin, J., Blackburn, E., Hecht, F.M., Kristeller, J., Maninger, N., Kuwata, M., Bacchetti, P., Havel, P., & Epel, E. Changes in stress, eating, and metabolic factors are related to changes in telomerase activity in a randomized mindfulness intervention pilot study. Psychoneuroendocrinology. 2012 Jul;37(7):917-28. Epub 2011 Dec 14.

Tomiyama AJ, O'Donovan A, Lin J, Puterman E, Lazaro A, Chan J, Dhabar F, Wolkowitz O, Kirschbaum C, Blackburn E, Epel E. Does cellular aging relate to patterns of allostasis? An examination of basal and stress reactive HPA axis activity and telomere length. Physiol Behav. 2012 April 12;106(1):40-5. Epub 2011 Nov 28.

Krauss J, Farzaneh-Far R, Puterman E, Na B, Lin J, Epel E, Blackburn E, Whooley MA. Physical fitness and telomere length in patients with coronary heart disease: findings from the heart and soul study. PLoS One. 2011;6(11):e26983. Epub 2011 Nov 9. PMCID: PMC3212515

Steptoe A, Hamer M, Butcher L, Lin J, Brydon L, Kivimäki M, Marmot M, Blackburn E, Erusalimsky JD. Educational attainment but not measures of current socioeconomic circumstances are associated with leukocyte telomere length in healthy older men and women. Brain Behav Immun. 2011 Oct;25(7):1292-8. Epub 2011 Apr 23. [PMCID: Not applicable/not publically funded]

Kroenke CH, Pletcher MJ, Lin J, Blackburn E, Adler N, Matthews K, Epel E. Telomerase, telomere length, and coronary artery calcium in black and white men in the CARDIA study. Atherosclerosis. 2012 Feb;220(2):506-12. Epub 2011 Nov 9.

Prather AA, Puterman E, Lin J, O'Donovan A, Krauss J, Tomiyama AJ, Epel ES, Blackburn EH. Shorter leukocyte telomere length in midlife women with poor sleep quality. J Aging Res. 2011;2011:721390. Epub 2011 Oct 20. PMCID: PMC3199186

Njajou, O T, Cawthon, R M, Blackburn, E H, et al. (2011). Shorter telomeres are associated with obesity and weight gain in the elderly. International Journal of Obesity (London). 2011 Oct 18. doi: 10.1038/ijo.2011.196 [Epub ahead of print].

Brydon, L, Lin, J, Butcher, L, et al. Hostility and Cellular Aging in Men from the Whitehall II Cohort. Biol Psychiatry. 2011 Oct 3 [Epub ahead of print]. [PMCID: Not applicable/not publically funded]

Hoen PW, de Jonge P, Na BY, Farzaneh-Far R, Epel E, Lin J, Blackburn E, Whooley MA. Depression and leukocyte telomere length in patients with coronary heart disease: data from the heart and soul study. Psychosom Med. 2011 Sep;73(7):541-7. Epub 2011 May 19. PMCID: PMC3161173

Lin, J, Epel, E, & Blackburn, E. Telomeres and lifestyle factors: Roles in cellular aging. Mutation research. Fundamental and Molecular Mechanisms of Mutagenesis. 2011 Aug 22. [Epub ahead of print]. [PMCID: Not applicable/not publically funded]

Kroenke, C H, Epel, E, Adler, N, et al. Autonomic and adrenocortical reactivity and buccal cell telomere length in kindergarten children. Psychosomatic medicine, 73(7), 533-40. Epub 2011 Aug 26. PMCID: PMC3212037

Aviv A, Hunt Sc, Lin J, Cao X, Kimura M, Blackburn E. Impartial comparative analysis of measurement of leukocyte telomere length/DNA content by Southern blots and qPCR. Nucleic Acids Res. 2011 Aug 8. [Epub ahead of print].

Entringer S, Epel,ES, Kumsta R, Lin J, Helhammer DH Blackburn EH, Wüst S, Wadwha PD.  Stress exposure in intrauterine life is associated with shorter telomere length in young adulthood. Proc Natl Acad Sci USA. 2011 Aug 3. [Epub ahead of print].

O’Donovan, A., Pantell, M., Puterman, E., Dhabhar, F.S., Blackburn, E.H., Yaffe, K., Cawthon, R.M., Opresko, P.L., Hsueh, W.C., Satterfield, S., Newman, A.B., Ayonayon, H.N., Rubin, S.M., Harris, T.B., & Epel, E.S. for the Health Aging and Body Composition Study (2011). Cumulative inflammatory load is associated with short leukocyte telomere length in the Health, Aging and Body Composition Study. PLoS One. 2011;6(5):e19687. Epub 2011 May 13. PMCID: PMC3094351

Wolkowitz O, Mellon SH, Epel ES, Lin J, Dhabhar FS, Su Y, Reus VI, Rosser R, Burke HM, Kupferman E, Compagnone M, Nelson JC, and EH Blackburn. Leukocyte Telomere Length in Major Depression: Correlations with Chronicity, Inflammation and Oxidative Stress - Preliminary Findings. PLoS One. 2011; 6(3): e17837. [Epub 2011 March 23]. PMCID: PMC3063175

Wolkowitz, OM, Mellon, SM, Epel, ES, Lin, J, Reus, VI, Rosser, R, Burke, H, Compagnone, M, Nelson, JC, Dhabar, FS and EH Blackburn. Resting leukocyte telomerase activity is elevated in major depression and predicts treatment response. Mol Psychiatry. 2011 Jan 18. [Epub ahead of print]

Williams, T L, Levy, D L, Maki-Yonekura, S, Yonekura, K and EH Blackburn. Characterization of the yeast telomere nucleoprotein core: Rap1 binds independently to each recognition site. J Biol Chem. [EPub Sep 7 2010].  (2010) PMCID: PMC2975205 [Available on 2011/11/12].

Stohr, B, Xu, L and Blackburn EH. The Terminal Telomeric DNA Sequence Determines the Mechanism of Dysfunctional Telomere Fusion. Molecular Cell. Jul 30;39(2):307-14. (2010) PMCID: PMC2920734 [Available on 2011/7/1].

Puterman, E, Lin, J, Blackburn, E, et al. (2010). The power of exercise: buffering the effect of chronic stress on telomere length. PloS one, 5(5), e10837-. (2010) PMCID: PMC2877102

O’Donovan, A., Lin, J., Wolkowitz, O., Dhabhar, F.S., Tillie, J.M., Blackburn, E., and Epel, E. Pessimism correlates with leukocyte telomere shortness and elevated interleukin-6 in post-menopausal women. Brain Behav Immun. 23(4):446-449. PMCID: PMC2719778.

O’Donovan, A, Epel, E, Lin, J, Wolkowitz, O, Cohen, B, Maguen, S, Metzler, T, Lenoci, M, Blackburn, E, and Neylan, TC. Childhood trauma associated with short leukocyte telomere length in post-traumatic stress disorder. J Biol Psy. Biol Psychiatry. 2011 Apr 12. [Epub ahead of print]

Njajou, OT, Blackburn, EH, Pawlikowska, L, Mangino, M, et al. A common variant in the telomerase RNA component is associated with short telomere length. PloS one, 5(9), e13048-. (2010) PMCID: PMC2946401.

Njajou OT, Hsueh WC, Blackburn EH, Newman AB, Wu SH, Li R, Simonsick EM, Harris TM, Cummings SR, Cawthon RM; Health ABC study. Association between telomere length, specific causes of death, and years of healthy life in health, aging, and body composition, a population-based cohort study. J Gerontol A Biol Sci Med Sci. 2009 Aug; 64(8):860-4. Epub 2009 May 12. PMCID: PMC2981462.

Makovets, S and EH Blackburn. DNA damage signaling prevents deleterious telomere addition at DNA breaks. Nature Cell Biol. 11(11):1383-1386. (2009) PMCID: PMC2806817.

Lin J, Kroenke CH, Epel E, Kenna HA, Wolkowitz OM, Blackburn E, Rasgon NL. Greater endogenous estrogen exposure is associated with longer telomeres in postmenopausal women at risk for cognitive decline. Brain Research. 2011 Mar 16;1379:224-31. Epub 2010 Oct 18. PMCID: PMC3057451

Lin J, Epel E, Cheon J, Kroenke C, Sinclair E, Bigos M, Wolkowitz O, Mellon S and E Blackburn. Analyses and comparisons of telomerase activity and telomere length in human T and B cells: Insights for epidemiology of telomere maintenance. J Immunol Methods. 2010 Jan 31; 352(1-2):71-80.  [Epub 2009 Oct 21]. [PMCID-in Progress]

Li, S, Makovets, S, Matsuguchi, T, Blethrow, JD, Shokat, KM, and E.H. Blackburn. Cdk1-dependent phosphorylation of Cdc13 coordinates telomere elongation during cell-cycle progression. Cell. 136: 50-61 (2009). PMCID: PMC2642970. 

Jacobs TL, Epel ES, Lin J, Blackburn EH, Wolkowitz OM, Bridwell DA, Zanesco AP, Aichele SR, Sahdra BK, Maclean KA, King BG, Shaver PR, Rosenberg EL, Ferrer E, Wallace BA, Saron CD. Intensive meditation training, immune cell telomerase activity, and psychological mediators. Psychoneuroendocrinology. 2010 Oct 29. 2011 Jun;36(5):664-81. Epub 2010 Oct 29.

Humphreys J, Epel ES, Cooper BA, Lin J, Blackburn EH, Lee KA. Telomere Shortening in Formerly Abused and Never Abused Women. Biol Res Nurs. 2011 Mar 8. [Epub ahead of print]

Farzaneh-Far R, Lin J, Epel ES, Lapham K, Blackburn EH and Whooley MA. Telomere length trajectory and its determinants in persons with coronary artery disease: longitudinal findings from the Heart and Soul Study. PLOS One. 2010 Jan 8; 5(1):e8612. PMCID: PMC2797633

Farzaneh-Far R, Lin J, Epel ES, Blackburn EH and Whooley MA. Association of marine omega-3 fatty acid levels with telomeric aging in patients with coronary heart disease. JAMA. 2010 Jan 20; 303(3):250-7. PMCID: PMC2819264

Epel, ES, Merkin, SS, Cawthon, R,  Blackburn, EH, Adler, NE, Pletcher ,MJ  and Seeman, TE. The Rate of Leukocyte Telomere Shortening Predicts Mortality from Cardiovascular Disease in Elderly Men. Aging. 1: 81- 88. (2009). PMCID: PMC2830080.

Epel ES, Lin, J, Dhabar, FS, Wolkowitz, OM, Puterman, E, Karan, L, Blackburn, EH. Dynamics of telomerase activity in response to acute psychological stress. Brain Behav Immun. 2009 Dec 16 [Epub ahead of Print] PMCID: PMC2856774