Homeostasis is a general mechanism by which a cell responds to a perturbation and maintains a constant physiology. In the nervous system, disruption of synaptic homeostasis is thought to contribute to the etiology of diseases such as epilepsy. Currently, very little is known about the molecular mechanisms that mediate this process. I am interested in the homeostatic control of synaptic function, and in particular the molecular mechanisms that monitor, signal, and execute changes in excitability and function. Such mechanisms can work on a general level, across many synapses, or take place with synapse-specific changes. I am using a combination of genetics, electrophysiology, and imaging approaches to study these processes.