The mechanisms controlling the balance of excitation
and inhibition in the nervous system are poorly understood.
Recent studies from our lab and others suggest that
homeostatic mechanisms monitor and regulate the levels
of cellular excitation in the nervous system, and a
model for the homeostatic regulation of neural excitability
has been developed at the Drosophila neuromuscular synapse.
For my research, I am interested in addressing how
neurons maintain their electrical signaling properties
during development and throughout life. To do this,
I am using electrophysiology to characterize homeostatic
regulation of synaptic function in greater detail. I
am also combining Drosophila genetics and electrophysiology
to isolate new genes involved in homeostasis.