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Heather Heerssen- Postdoc

PhD Harvard University
Sustained neurotransmission during periods of intense presynaptic activity requires rapid recycling of synaptic vesicle membranes and proteins following neurotransmitter release. Many synaptic vesicles are recovered via compensatory endocytosis, a form of clathrin-mediatiated endocytosis. I will be using acute protein inactivation combined with live imaging of synaptic vesicle cycling to quantify the effects of endocytic proteins on the kinetics of synaptic vesicle reformation. In parallel, I will also be using functional genomic approaches to identify additional molecules involved in synaptic vesicle endocytosis.

 


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