Selected Lab Publications (through 2000)


O'Shea EK; Herskowitz I. (2000) The ins and outs of cell-polarity decisions. Nature Cell Biol. 2:39-41.

Herskowitz I. (1997) Building organs and organisms: elements of morphogenesis exhibited by budding yeast. CSH Symp. Quant. Biol. 62:57-63.

Herskowitz I; Park HO; Sanders S; Valtz N; Peter M. (1995) Programming of cell polarity in budding yeast by endogenous and exogenous signals. CSH Symp. Quant. Biol. 60:717-27.

- Mating

Butty AC; Pryciak PM; Huang LS; Herskowitz I; Peter M. (1998) The role of Far1p in linking the heterotrimeric G protein to polarity establishment proteins during yeast mating. Science 282:1511-6.

Philips J; Herskowitz I. (1998) Identification of Kel1p, a kelch domain-containing protein involved in cell fusion and morphology in Saccharomyces cerevisiae. J. Cell Biol. 143:375-89.

Philips J; Herskowitz I. (1997) Osmotic balance regulates cell fusion during mating in Saccharomyces cerevisiae. J. Cell Biol. 138:961-74.

Valtz N; Herskowitz I. (1996) PEA2 protein of yeast is localized to sites of polarized growth and is required for efficient mating and bipolar budding. J. Cell Biol. 135:725-739.

Valtz N; Peter M; Herskowitz I. (1995) FAR1 is required for oriented polarization of yeast cells in response to mating pheromones. J. Cell Biol. 131:863-73.

Chenevert J; Valtz N; Herskowitz I. (1994) Identification of genes required for normal pheromone-induced cell polarization in Saccharomyces cerevisiae. Genetics 136(4):1287-96.

Chenevert J; Corrado K; Bender A; Pringle J; Herskowitz I. (1992) A yeast gene (BEM1) necessary for cell polarization whose product contains two SH3 domains. Nature 356:77-9.

- Budding

Park HO; Sanson A; Herskowitz I. (1999) Localization of bud2p, a GTPase-activating protein necessary for programming cell polarity in yeast to the presumptive bud site. Genes and Dev. 13:1912-7.

Sanders SL; Gentzsch M; Tanner W; Herskowitz I. (1999) O-Glycosylation of Axl2/Bud10p by Pmt4p is required for its stability,localization, and function in daughter cells. J. Cell Biol. 145:1177-88.

Park HO; Bi E; Pringle JR; Herskowitz I. (1997) Two active states of the Ras-related Bud1/Rsr1 protein bind to different effectors to determine yeast cell polarity. Proc. Nat. Acad. Sci. USA 94:4463-8.

Sanders SL; Herskowitz I. (1996) The BUD4 protein of yeast, required for axial budding, is localized to the mother/BUD neck in a cell cycle-dependent manner. J. Cell Biol. 134: 413-27.

Chant J; Mischke M; Mitchell E; Herskowitz I; Pringle JR. (1995) Role of Bud3p in producing the axial budding pattern of yeast. J. Cell Biol. 129(3):767-78.

Park HO; Chant J; Herskowitz I. (1993) BUD2 encodes a GTPase-activating protein for Bud1/Rsr1 necessary for proper bud-site selection in yeast. Nature 365:269-74.


Grether ME; Herskowitz I. (1999) Genetic and biochemical characterization of the yeast spo12 protein. Mol. Biol. of the Cell 10:3689-703.

Chu S; DeRisi J; Eisen M; Mulholland J; Botstein D; Brown PO; Herskowitz I. (1998) The transcriptional program of sporulation in budding yeast. Science 282:699-705.

Chu S; Herskowitz I. (1998) Gametogenesis in yeast is regulated by a transcriptional cascade dependent on Ndt80. Mol.Cell 1:685-96.

- Signalling

O'Rourke SM; Herskowitz I. (1998) The Hog1 MAPK prevents cross talk between the HOG and pheromone response MAPK pathways in Saccharomyces cerevisiae. Genes Dev. 12:2874-86.

Banuett F. (1998) Signalling in the yeasts: an informational cascade with links to the filamentous fungi. Microbiol. Mol. Biol. Rev. 62:249-74.

Gray JV; Ogas JP; Kamada Y; Stone M; Levin DE; Herskowitz I. (1997) A role for the Pkc1 MAP kinase pathway of Saccharomyces cerevisiae in bud emergence and identification of a putative upstream regulator. EMBO J. 16:4924-37.

Peter M; Neiman AM; Park HO; van Lohuizen M; Herskowitz I. (1996) Functional analysis of the interaction between the small GTP binding protein Cdc42 and the Ste20 protein kinase in yeast. EMBO J. 15:7046-59.

Herskowitz I. (1995) MAP kinase pathways in yeast: for mating and more. Cell 80:187-97.

Neiman AM; Herskowitz I. (1994) Reconstitution of a yeast protein kinase cascade in vitro: activation of the yeast MEK homologue STE7 by STE11. Proc. Nat. Acad. Sci. USA 91:3398-402.

Neiman AM; Stevenson BJ; Xu HP; Sprague GF Jr; Herskowitz I; Wigler M; Marcus S. (1993) Functional homology of protein kinases required for sexual differentiation in Schizosaccharomyces pombe and Saccharomyces cerevisiae suggests a conserved signal transduction module in eukaryotic organisms. Mol. Biol. Cell 4:107-20.


- Assymmetry

Takizawa PA; Sil A; Swedlow JR; Herskowitz I; Vale RD. (1997) Actin-dependent localization of an RNA encoding a cell-fate determinant in yeast. Nature 389(6646):90-3.

Sil A; Herskowitz I. (1996) Identification of an assymmetrically localized determinant, Ash1p, required for lineage-specific transcription of the yeast HO gene. Cell 84:711-722

Horvitz HR; Herskowitz I. (1992) Mechanisms of asymmetric cell division: two Bs or not two Bs, that is the question. Cell 68:237-55.

- Transcriptional Control

Tabtiang RK; Herskowitz I. (1998) Nuclear proteins Nut1p and Nut2p cooperate to negatively regulate a Swi4p-dependent lacZ reporter gene in Saccharomyces cerevisiae. Mol. Cell. Biol. 18:4707-18.

Kruger W; Peterson CL; Sil A; Coburn C; Arents G; Moudrianakis EN; Herskowitz I. (1995) Amino acid substitutions in the structured domains of histones H3 and H4 partially relieve the requirement of the yeast SWI/SNF complex for transcription. Genes Dev. 9:2770-9.

Peterson CL; Herskowitz I. (1992) Characterization of the yeast SWI1, SWI2, and SWI3 genes, which encode a global activator of transcription. Cell 68:573-83.

- Cell Cycle Control and Cell Death

Shaham S; Shuman MA; Herskowitz I. (1998) Death-defying yeast identify novel apoptosis genes. Cell 92:425-7.

Gerber MR; Farrell A; Deshaies RJ; Herskowitz I; Morgan DO. (1995) Cdc37 is required for association of the protein kinase Cdc28 with G1 and mitotic cyclins.Proc. Nat. Acad. Sci. USA 92:4651-5.

Peter M; Herskowitz I. (1994) Joining the complex: cyclin-dependent kinase inhibitory proteins and the cell cycle. Cell 79:181-4.

Peter M; Herskowitz I. (1994) Direct inhibition of the yeast cyclin-dependent kinase Cdc28-Cln by Far1. Science 265:1228-31.

Espinoza FH; Ogas J; Herskowitz I; Morgan DO. (1994) Cell cycle control by a complex of the cyclin HCS26 (PCL1) and the kinase PHO85.Science 266:1388-91.

Li JJ; Herskowitz I. (1993) Isolation of ORC6, a component of the yeast origin recognition complex by a one-hybrid system. Science 262(:1870-4.

Peter M; Gartner A; Horecka J; Ammerer G; Herskowitz I. (1993) FAR1 links the signal transduction pathway to the cell cycle machinery in yeast. Cell 73:747-60.

Chang F; Herskowitz I. (1992) Phosphorylation of FAR1 in response to alpha-factor: a possible requirement for cell-cycle arrest. Mol. Biol. Cell 3:445-50.

Ogas J; Andrews BJ; Herskowitz I. (1991) Transcriptional activation of CLN1,CLN2, and a putative new G1-cyclin (HCS26) by SWI4, a positive regulator of G1-specific transcription. Cell 66:1015-1026.

- Ustilago Maydis

Banuett F; Herskowitz I. (1996) Discrete developmental stages during teliospore formation in the corn smut fungus, Usitlago Maydis. Development 122:2965-76.

Banuett F. (1995) Genetics of Ustilago maydis, a fungal pathogen that induces tumors in maize. Ann. Rev. Gen 29:179-208.

Banuett F; Herskowitz I. (1994) Identification of fuz7, a Ustilago maydis MEK/MAPKK homolog required for a-locus-dependent and -independent steps in the fungal life cycle. Genes Dev. 8:1367-78.

Banuett F; Herskowitz I. (1994) Morpholgical transitions in the life cycle of Ustilago maydis and their genetic control by the a and b loci. Exper. Mycology 18: 247-266.

Banuett F. (1992) Ustilago maydis, the delightful blight Trends Genet. 8:174-80.

Trueheart J; Herskowitz I. (1992) The a locus governs cytoduction in Ustilago maydis. J. Bacteriol. 174:7831-3.

Banuett F. (1991) Identification of genes governing filamentous growth and tumor induction by the plant pathogen Ustilago maydis. Proc. Nat. Acad. Sci. USA 88:3922-6.

Schulz B; Banuett F; Dahl M; Schlesinger R; Schafer W; Martin T; Herskowitz I; Kahmann R. (1990) The b alleles of U. maydis, whose combinations program pathogenic development, code for polypeptides containing a homeodomain-related motif. Cell 60:295-306.

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