University of California San Francisco                        December 10, 2010

CURRICULUM VITAE

 

DIDIER Y. R. STAINIER                                                                                                DOB: 10/31/1963

Professor                                                                                                          citizenship: American/Belgian

Department of Biochemistry & Biophysics

School of Medicine

 

Director of the UCSF Fellows Program, Co-Director of The Developmental and Stem Cell Biology Program, Associate Director of The Liver Center; Member of the Tetrad and BMS Graduate Programs, Cardiovascular Research Institute, Diabetes Center, Institute for Regeneration Medicine, Cancer Center, and Human Genetics Institute.

 

email: didier.stainier@ucsf.edu                                                  

www: http://www.ucsf.edu./dyrslab/                                                      

 

EDUCATION

 

Dates

Institution and Location

Degrees conferred

Major Subject

1979-1981

United World Colleges,

Wales, U.K.

International Baccalaureate, Highest Honors

Biology, Physics, Math

 

1981-1982

Université de Liège,

Liège, Belgium

Certificate in Biology

Biology

1982-1984

Brandeis University,

Waltham, MA

B.A. Summa cum laude

Biology

1984-1990

Harvard University,

Cambridge, MA

Ph.D.

Dr. Walter Gilbert

Biochemistry and Molecular Biology

 

RESEARCH AND PROFESSIONAL EXPERIENCE

 

Principal Positions Held

 

Dates

Institution and Location

Position

1990-1994

Massachusetts General Hospital,

Harvard Medical School, Boston, MA

Postdoctoral Fellow

Dr. Mark Fishman

1995-present

Department of Biochemistry & Biophysics, University of California, San Francisco

Assistant, Associate (2000), Full (2003)

Professor

 

HONORS AND AWARDS

1982-1984

Wien International Scholar, Brandeis University

 

1983

Elihu A. Silver Prize for Undergraduate Research in Science, Brandeis University

 

1984

Dr. Joseph Garrison Parker Prize in Biology, Brandeis University

 

1984

Phi Beta Kappa, Brandeis University

 

1991-1994

Helen Hay Whitney Foundation Postdoctoral Fellow

 

1995

Louis N. Katz Basic Science Research Prize Finalist, American Heart Association

 

1995-2000

Packard Foundation Fellow in Science and Engineering

 

1996-1998

Basil O'Connor Scholar, March of Dimes Foundation

 

2000-2003

Established Investigator, American Heart Association

 

2002

Mossman Award in Developmental Biology, American Association of Anatomists

2003-2004

Annual Byers Award in Basic Science, UCSF

2003

Outstanding Faculty Mentorship Award, UCSF

2003-2006

NIH DEV1, study section Chair

2008

J.W. Jenkinson Memorial Lectureship, Oxford University

2008

Fellow of the American Association for the Advancement of Science

 

KEYWORDS/RESEARCH INTERESTS

Vertebrate organ formation/cardiovascular development/endoderm, liver, pancreas and gut development/ regeneration/stem cell differentiation/lipid transport/gluconeogenesis/metabolism

 


PROFESSIONAL ACTIVITIES

Editorial boards

1997-2007               Editorial Board Member, Developmental Biology

2001-2006               Associate Editor, Developmental Dynamics

2002-2003               Faculty of 1000, Faculty Member

2004-present           Editorial Board Member, Development

2004-present           Editorial Board Member, Zebrafish

2004-present           Editorial Board Member then Section Editor, BMC Developmental Biology

2006-present           Managing Editor, Mechanisms of Development

 

Manuscript review

Nature, Science, Cell, Genes and Development, Developmental Cell, Nature Genetics, Nature Cell Biology, Nature Medicine, Nature Methods, Nature Reviews Genetics, Nature Chemical Biology, PLoS Biology, PLoS Genetics, PNAS, Current Biology, EMBO Journal, TIGS, TCB, Development, Developmental Biology, Developmental Dynamics, Mechanisms of Development, MBC, J. of Experimental Biology, FASEB journal, Zebrafish, Circulation Research, Blood, JCI, Genome Research, Hepatology, Diabetes, Pancreas, Lipids,...

 

Grant review

Ad Hoc reviewer for NIH, NSF, HHMI, as well as various scientific organizations in the EU, Canada, the United Kingdom, Ireland, Germany, the Netherlands, Belgium, France, Israel, Singapore, Taiwan and Hong Kong.

1996-2000                              American Heart Association (Western Affiliates) study section member

1999                       National Science Foundation, Developmental Mechanisms study section member

2000                       American Cancer Society (National), DDC Peer Review committee member

2000-2002               American Heart Association (National Committee) study section member

2001                       NIH CDF5 study section ad hoc member (plus ad hoc on special study sections, PPGs)

2001                       NASA, Developmental Biology study section member

2002-present           NIH ECS, VCMB, MET, SBDD, CADO, SEP and GCMB study sections ad hoc

2003                       European Commission FP6 Evaluation member

2003-2006                              NIH DEV1, study section Chair

2008                       Special Emphasis Panel: Tools for Zebrafish Research, study section Chair

2009-present           Juvenile Diabetes Research Foundation study section member

2009                       European Commission FP7 Evaluation member

2010-2012               NIH College of Center for Scientific Review member

2011                       Deutsche Forschungsgemeinschaft Excellence Initiative reviewer, Germany

 

Service to Professional Organizations

1998-2000         Member, NIH Advisory Committee on Zebrafish Genetics and Genomics

2001-2004                  Society of Dev. Biology Board of Directors, elected West Coast Representative

2002                 Co-organizer, 5th International Meeting on Zebrafish Development and Genetics,

                        Madison, WI

2003                 External Scientific Advisory Committee, Molecular Cardiovascular Medicine Group,

Leuven, Belgium

2003, 2004        Member, then Chair, Mossman Award Selection Committee, American Association of Anatomists

2004-2009         Member, External Advisory Committee, Zebrafish International Resource Center

2004-2008         Selection Committee, Strategic Conference of Zebrafish Investigators

2005-2008         Member, Zebrafish Investigators Steering Committee

2006                 Keystone Symposia, Development Study Group 

2007-present     Regeneration Project, Gainesville, FL., Scientific Advisory Board

2008                 External Scientific Advisory Committee, IMCB, Singapore

2009-present     Keystone Symposia's Scientific Advisory Board, ad hoc then full member            

2010                 Scientific advisory Committee for IVBM 2010 (International Vascular Biology Meeting)

2010-2013         External Advisor, BOLD (European Network on ‘Biology of Liver and Pancreatic Development and Disease’)

2010                 Scientific Academic Advisory Committee, Weizmann Institute of Science

Other

2004                 Scientific Advisory Committee for a special publication by Nature entitled: Milestones in

                        Development.

2008                 Co-Organizer, Japanese-Bay Area Vertebrate Organogenesis Conference

2011                 Speaker and Participant, NICHD Vision Workshop on Development

2011                 Co-Organizer, UNIA Workshop on ‘Liver and Pancreas Development and Disease’, Baeza,

                        Spain

 

INVITED PRESENTATIONS (since 2006)

Named lectures and plenary talks are indicated in bold.

2006

INTERNATIONAL:

British Society of Developmental Biology Annual meeting, York, England, session chair & speaker

3rd Canadian Developmental Biology Conference, Mont-Tremblant, Québec, Canada

Max Delbrück Centrum Conference on Epithelial organization and Organ development, Berlin, Germany

3rd EMBO Conference on Regeneration and Tissue Repair Ascona, Switzerland

4th International Kloster Seeon Meeting on "Angiogenesis", Germany

KIX Symposium on “Genomic medical science and heart disease” Osaka, Japan, plenary speaker

Hospital for Sick Children, Toronto, Canada

 

NATIONAL:

Burnham Institute, La Jolla, CA

Keystone Symp. ‘Molecular Mechanisms of Cardiac Disease & Regeneration’, speaker, plenary session chair

NAVBO, Developmental Vascular Biology Workshop, Asilomar, CA

UCLA Institute for Pure and Applied Mathematics, Angiogenesis, NeoVascularization and

Morphogenesis workshop

UCSF liver center retreat, Mill valley, CA

FASEB conference on mechanisms of liver growth, development and disease, Snowmass, CO

Oregon Health Sciences University, Cell and Developmental Biology, Portland, OR

Developmental Dynamics symposium, Salt Lake City, UT

UCSF, Minimed series

University of Pennsylvania School of Medicine, Molecular Cardiology Research Center, Philadelphia, PA

Gordon Research Conference on endothelial cell phenotypes in health & disease, Biddeford, ME

University of Chicago Medical School (invited to apply for chair of Molecular Genetics and Cell Biology)

Vasculata 2006, UCLA, instructor

University of Michigan Medical School, Ann Arbor, MI

UCSF BMS seminar series, San Francisco, CA

University of Massachusetts Medical School, Worcester, MA

Harvard Medical School, Children’s Hospital, Boston, MA (invited to apply for a chaired position)

 

2007

INTERNATIONAL:

National Center for Biotechnology, Madrid, Spain

Biozentrum, Basel, Switzerland

First Pan American Congress in Developmental Biology, Cancun, Mexico

ComBio, Sydney, Australia, Plenary speaker

ComBio, Sydney, Australia, Symposium speaker

University of Queensland, Brisbane, Australia

‘Drilling into life´s depth – innovative methods in molecular biology’, student organized symposium at the

      University of Würzburg, Germany

Foundation for Biomedical Research of the Academy of Athens, Greece

Zebrafish Development and Disease Course, Hubrecht Laboratory, Utrecht, the Netherlands

 

NATIONAL:

Systems Medicine Workshop, NHLBI, Bethesda, MD

New York University Medical School, Skirball Institute.

UCSF/Karolinska Institute Stem Cell Symposium

UCSD Cardiovascular Science Conference

West Coast SDB meeting, Asilomar, CA, session chair and speaker

Regenerative Medicine Seminar, Stanford University, Palo Alto, CA

Keystone Symposium on Tissue engineering and developmental biology, Snowbird, UT

University of TexasAustin; Section of Molecular Cell and Developmental Biology Annual Retreat,

      Plenary speaker (declined)

American Diabetes Association, Chicago, IL

4th Annual Symposium of the AHA Council on Basic Cardiovascular Sciences – Cardiovascular Repair and

      Regeneration: Structural and Molecular Approaches in the Cellular Era, Keystone, CO

FASEB conference on gastrointestinal tract XII: The molecular and integrative basis for GI

      development, homeostasis & disease, Snowmass, CO

Zebrafish investigators' workshop, Asilomar, CA

Princeton University, Department of Molecular Biology, invited by the graduate students

UNC, Chapel Hill, NC

 

2008

INTERNATIONAL:

“From Developmental Biology to tissue regeneration” international workshop, Santiago, Chile

International Symposium on ‘Stem cells in Development, Regeneration and Disease, Bangalore, India

Temasek Life Sciences Laboratory, Singapore (2 lectures and 1 seminar)

Centro Nacional de Investigaciones Cardiovasculares-CNIC, Madrid, Spain

Distinguished Scientist Lecture Series, Max Planck Institute for Developmental Biology, Tübingen, Germany,

      invited by the graduate students

J.W. Jenkinson Memorial Lectureship, University of Oxford

41st Japanese Society of Developmental Biology, International Society of Developmental Biology joint

      meeting, Tokushima City, Japan

XX International Congress of Genetics 2008, Berlin, Germany

Annual Conference, EU FP6 Integrated Project ‘HeartRepair’, Madrid, Spain

Journée Claude Bernard de la Société de Biologie, Paris, France (declined)

4th meeting of the Latin American Society of Developmental Biology, Buenos Aires, Argentina

 

NATIONAL:

NAVBO, Developmental Vascular Biology Workshop, Asilomar, CA

FASEB conference on mechanisms of liver growth, development and disease, Snowmass, CO

Iowa State University, Ames, Iowa

Teratology Society 48th Annual meeting, Monterey, CA

2008 Beta cell Biology Consortium Retreat Plenary Speaker, Washington DC

Case Western Reserve University, Cleveland, OH (invited by the graduate students)

8th International Meeting on Zebrafish Development and Genetics, Madison, WI

Developmental Biology Symposium at the University of Minnesota, Minneapolis, MN

Woods Hole Embryology course, Woods Hole, MA

Tufts University, Boston, MA

UCSF, Cardiology Grand Rounds

Gordon Research Conference on Molecular Cell Biology, New London, NH

Keystone Symposium on Pathological and Physiological Regulation of Cardiac Hypertrophy, (declined)

UC Davis, Davis, CA

University of Michigan Medical School, Ann Arbor, MI

SF-Japan Joint meeting on vertebrate organogenesis, San Francisco, CA

Dana-Farber Cancer Institute, Boston, MA

ASCB Annual Meeting, Symposium speaker, San Francisco, CA

 

2009

INTERNATIONAL:

Belgian Society for Cell and Developmental Biology, Leuven, Belgium

Keystone Symposium on Stem Cell Niche interactions, Whistler, Canada

66th KSBMB Annual Meeting, Seoul, South Korea

Korea University, Seoul, South Korea

Kyungpook National University, Daegu city, South Korea

Chungnam National University, Daejeon city, South Korea

KAIST, Daejeon city, South Korea

Center for Regenerative Therapies Dresden, Summer Conference, Keynote Speaker, Germany

Advances in Heart Development: from molecules to cures, Fondation des Treilles, France

Workshop, Mechanisms of Organ Regeneration in Model Systems, Baeza, Spain

Center for Molecular Biosciences meeting, Plenary speaker, Innsbruck, Austria

 

NATIONAL:

University of Miami, Cell Biology and Anatomy, Miami, FL

Tulane University, New Orleans, LA

Zebrafish investigators' workshop, Asilomar, CA

Gordon Research Conference on Vascular Biology, Ventura, CA, (declined)

Northwest Society of Developmental Biology, Plenary talk, Friday Harbor labs, (declined)

Duke University, DSCB colloquium, Durham, NC

Insittute of Regenerative Medicine retreat, Asilomar, CA

Digestive Disease Week, State-of-the-Art Lecture, Chicago, IL

Riley Heart Center Symposium on Cardiac Development, Indianapolis, IN

Keystone Symposium on Cardiac Disease: Development, Regeneration, and Repair, (declined)

American Liver Foundation meeting, Boston, MA

Vanderbilt University, Nashville, TN

Rachford Lecture, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH

National Human Genome Research Institute, NIH, Bethesda, MD

UC Berkeley, Department of Nutritional Sciences and Toxicology, Berkeley, CA

 

2010

INTERNATIONAL:

Biology of Liver and Pancreas Development and Disease (BOLD), Birmingham, UK

8th Annual CDB symposium, Frontiers in Organogenesis, RIKEN CDB, Kobe, Japan

Regulatory Peptides 2010 Meeting, Belfast, Northern Ireland

5th EMBO Conference on Regeneration and Tissue Repair Lisbon, Portugal

Heraeus meeting on Self-Organization in Cell Assemblies and Tissues, Bad Honnef, Germany (declined)

New Frontiers in Transcriptional Regulation, BOLD Network meeting, Cambridge, UK

Frontiers in Developmental Biology, Weizmann Institute, Israel

16th International Conference of the International Society of Differentiation, Nara, Japan

Max Planck Institutes colloquium on ‘Frontiers in Cardiopulmonary Research’, Munich, Germany

Annual Meeting of Molecular Biology, BMB2010, Kobe, Japan

University of Tokyo, Japan (declined)

Institute of Genetics and Molecular and Cellular Biology, Strasbourg, France

 

NATIONAL:

NAVBO, Developmental Vascular Biology Workshop, Asilomar, CA

Keystone Symposium on Angiogenesis in Health and Disease, Keystone, CO

Juvenile Diabetes Research Foundation Niche Symposium, New York, NY

Inaugural symposium on Diabetes, UCSD Pediatric Diabetes Research Center

National Heart, Lung and Blood Institute, NIH, Bethesda, MD

Inaugural Cold Spring Harbor symposium on Vertebrate Organogenesis, CSH, NY

Novartis Institute for Biomedical Research, Cambridge, MA

3rd Annual Penn Cardiovascular Institute Symposium, University of Pennsylvania, Philadelphia, PA

15th International Symposium on the Cells of Hepatic Sinusoid, State-of-the-Art lecture, Pasadena, CA

University of Texas at Austin, Austin, TX

Stanford University Frontiers in Biological Research Seminar Series, Palo Alto, CA

International Vascular Biology Meeting 2010, UCLA, Los Angeles, CA

Texas A&M Molecular &Cellular Medicine, College Station, TX

UCLA Interdepartmental Genetics Seminar Series, Los Angeles, CA

FASEB conference on mechanisms of liver growth, development and disease, Snowmass, CO

Heart Failure Society of America Meeting, San Diego, CA

3rd Warshaw Developmental Biology Symposium, Yale, New Haven, CT

Maternal, Fetal and Neonatal Health Research Symposium, UCSF, San Francisco, CA

American Society of Hematology, Orlando, FL

 

2011

INTERNATIONAL:

EMBO meeting on advances in Stem Cell research, Paris, France

New Frontiers in Screening Technology, BOLD Network meeting, Karlsruhe, Germany

European Cystic Fibrosis Society, Tirrenia-Pisa, Italy (declined)

8th International Duodecim Symposium on Vascular Biology, Vanajanlinna, Hämeenlinna, Finland

International Society for Stem Cell Research 9th Annual Meeting, Toronto, Canada

2011 German Genetics Society Annual Meeting Plenary talk, Wuerzburg, Germany

UNIA Workshop on ‘Liver and Pancreas Development and Disease’, Baeza, Spain

 

NATIONAL:

Zebrafish investigators' workshop, Asilomar, CA

Keynote speaker, Gordon Research Conference on Vascular Cell Biology, Ventura, CA

Northwest Regional Society for Developmental Biology, Arthur Whitely Lecture, Friday Harbor, WA

Distinguished Lecture Series in Cardiovascular Biology, UT Southwestern Medical Center, Dallas, TX

National Institute of Child Health and Human Development Workshop on Development, Bethesda, MD

Diabetes Center, UCSF, San Francisco, CA

Mechanism of Organ Repair & Regeneration, Washington, DC (declined)

Beta Cell Biology Consortium Meeting, Washington, DC

Harvard Stem Cell Institute, Boston, MA

NIH Wednesday Afternoon Lecture Series, NIH Office of the Director, Bethesda, MD

Biology of Signaling in the Cardiovascular System Workshop, Hyannis, MA

 

UCSF COMMITTEES AND OTHER SERVICE (past 4 years)

2007-2008

Member of the Biochemistry/Biophysics Departmental Cabinet

Tetrad Graduate Curriculum Committee

PIBS executive Committee

BMS executive Committee

Steering Committee, Program in Craniofacial and Mesenchymal Biology

UCSF Fellows Steering Committee

Department of Biochemistry/Biophysics Animal Welfare Committee

UCSF Fellows Search Committee

GESCR Committee

Executive Committee and Annual Retreat Organizer, Developmental Biology Program

Associate Director, Liver Center

 

2008-2009

Co-Director and Annual Retreat Organizer, Developmental Biology Program

Associate Director, Liver Center

Member of the Biochemistry/Biophysics Departmental Cabinet

Tetrad Graduate Curriculum Committee

PIBS executive Committee

BMS executive Committee

Steering Committee, Program in Craniofacial and Mesenchymal Biology

UCSF Fellows Steering Committee

Department of Biochemistry/Biophysics Animal Welfare Committee

UCSF Fellows Search Committee

GESCR Committee

Gladstone Cardiovascular Search Committee

CVRI Search Committee

 

2009-2010

Co-Director and Annual Retreat Organizer, Developmental Biology Program

Associate Director, Liver Center

Co-Director, UCSF Fellows Program

Member of the Biochemistry/Biophysics Departmental Cabinet

Tetrad Graduate Curriculum Committee

PIBS executive Committee

BMS executive Committee

Steering Committee, Program in Craniofacial and Mesenchymal Biology

Department of Biochemistry/Biophysics Animal Welfare Committee

GESCR Committee

CVRI Search Committee

 

2010-2011

Director, UCSF Fellows Program

Co-Director, Developmental and Stem Cell Biology Program

Associate Director, Liver Center

Member of the Biochemistry/Biophysics Departmental Cabinet

Tetrad Graduate Curriculum Committee

PIBS executive Committee

BMS executive Committee

Department of Biochemistry/Biophysics Animal Welfare Committee

Cell Culture Facility Users Advisory Committee

CVRI Search Committee

 

TEACHING

Graduate Students currently in the lab

Anna Read (Tetrad, NSF fellowship, entered grad school 2008; joint student with Orion Weiner)

David Staudt (BMS, MSTP, entered grad school 2009)

 

 

 

Postdoctoral fellows currently in the lab

2006-present

Dan Hesselson, Ph.D.

University of Wisconsin, Madison, WI

Hillblom and JDRF Fellowships

2007-present

Jiandong Liu, Ph.D.

University of Michigan, Ann Arbor, MI

AHA postdoctoral Fellowship and Training Grant Fellowship

2007-present

Chunyue Yin, Ph.D.

Vanderbilt University, Nashville, TN

JDRF postdoctoral Fellowship

2007-present

Yoshiko Kametani, Ph.D.

Kyoto University, Japan

JSPS and Human Frontier Science Program Fellowship

2007-present

Shane Herbert, Ph.D.

University of Leeds, England

Sir Henry Wellcome Fellowship, UK

2007-present

Stephanie Woo, Ph.D.

University of Wisconsin, Madison, WI

CVRI training grant

2008-present

Olov Andersson, Ph.D.

Karolinska Institute, Sweden

Swedish Research Council and EMBO fellowships

2008-present

 

Philipp Gut, M.D.

 

University of Heidelberg

DFG postdoctoral Fellowship

2009-present

Marion Delous, Ph.D.

University Paris V, France

French Foundation Medical Fellowship

2009-present

Michael Housley, Ph.D.

Johns Hopkins University, Baltimore, MD

CIRM training grant

2009-present

Nikolay Ninov, Ph.D.

University of Barcelona, Spain

Canadian Diabetes Foundation Fellowship

2009-present

 

Benoit Vanhollebeke, Ph.D.

University of Brussels, Belgium

EMBO and Human Frontier Science Program Fellowships

2009-present

Sven Reischauer, Ph.D.

MPI, Tuebingen

DFG and AHA Postdoctoral Fellowships

2010-present

 

Kim Evason, M.D., Ph.D.

 

Washington University, St. Louis

Damon Runyon Fellowship

2010-present

Suphansa Sawamiphak, Ph.D.

Goethe University, Frankfurt, Germany

2010-present

Oliver Stone, Ph.D.

University of Bristol, England

2010-present

Aly Villasenor, Ph.D.

UT Southwestern Medical Center, Dallas, TX

 

Graduate Students who have left the lab and their current position

John Alexander, MD,PhD

Tetrad, AHA Fellowship

Molecular Medicine Fellow, UC San Francisco

Jeremy Reiter, MD, PhD

Tetrad, ARCS Fellowship

Assistant Professor, UC San Francisco

Emily Walsh, PhD

Tetrad,

HHMI Predoctoral Fellowship

Program Manager, Alnylam Pharmaceuticals

Sally Horne, PhD

Tetrad,

AHA Predoctoral Fellowship

Assistant Professor, University of Chicago School of Medicine

Holly Field, PhD

Tetrad

Medical Writer, Cambridge, MA

Le Trinh, PhD

BMS, NSF Predoctoral Fellowship

AHA Predoctoral Fellowship

Postdoctoral Fellow with Scott Fraser, Caltech

Nick Osborne, PhD

BMS, NSF Predoctoral Fellowship

Postdoctoral Fellow with Terry Magnuson, University of North Carolina

Kevin Vogeli, PhD

Tetrad,

NSF Predoctoral Fellowship

Medical Student, University of Southern California

Chantilly Munson, PhD

Tetrad,

NSF Predoctoral Fellowship

Assistant Professor, City College of San Francisco

Won-Suk Chung, PhD

BMS, Genentech Fellowship

CIRM Fellowship

Damon Runyon Postdoctoral Fellow with Ben Barres, Stanford University

Isla Cheung, PhD

Tetrad, ARCS Fellowship

Postdoctoral Fellow at UCSF

 

Postdoctoral Fellows who have left the lab and their current position (most recent listed last)

Leon Parker, PhD

NIH NRSA Fellowship

Staff Scientist, Genentech, Inc., So San Francisco, CA

Chi-Yip Ho, PhD

AHA Fellowship

Director, Microarray Facility, Lunenfeld Res. Inst., Toronto, Canada

Wayne Liao, PhD

AHA Fellowship

Program Manager, TLC pharmaceuticals, Mountain View, CA

Erik Kupperman, PhD

NSF Fellowship

UC President’s Fellowship

Senior scientist, Curagen, Cambridge

 

Birgitta Olofsson, PhD

 

Assistant Professor, Cambridge, England

Deborah Yelon, PhD

LSRF Fellowship

Burroughs Wellcome Fellowship

Professor, UC San Diego

Amy Sehnert, MD, PhD

PSDP Fellowship

NIH K08 Grant

AHA and BGIA Fellowships

Senior Director, Artemis Health, San Carlos, CA

 

Yutaka Kikuchi, PhD

HFSP Fellowship

Professor, Hiroshima University, Japan

Tom Bartman, MD, PhD

HHMI Postdoctoral Research Fellowship for Physicians

Assistant Professor, Cincinnati Children's Hospital

Medical Center

Julie Frantsve, PhD

CVRI Training Grant Fellowship

Assistant Director, ADA Council on Scientific Affairs

Heather Verkade, PhD

HFSP Fellowship

Assistant Professor, Monash University, Melbourne,

Australia

Federica Bertocchini, PhD

 

Postdoctoral Fellow, UCL, London, UK

Dimitris Beis, PhD

HFSP Fellowship

Assistant Professor, Academy of Athens, Greece

Tracy Mitchell, PhD

CVRI Training Grant Fellowship

Senior Scientist, Adnexus, Boston, MA

Elke Ober, PhD

AHA Fellowship

Assistant Professor, Mill Hill, London, UK

Suk-Won Jin, PhD

AHA Fellowship

Assistant Professor, Yale University,

New Haven, CT

Ian Scott, PhD

MRC of Canada Fellowship

Assistant Professor, Hospital for Sick Children, Toronto, Canada

Leonard D’Amico, PhD

NIH NRSA Fellowship

Postdoctoral Fellow, Seattle, WA

Tatiana Hochgreb, PhD

Pew Foundation Fellowship

Postdoctoral Fellow, Caltech, Pasadena, CA

Benno Jungblut, PhD

MPI Fellowship

AHA Fellowship

Junior Group Leader, MPI Bad Nauheim, Germany

Pia Aanstad, PhD

 

Assistant Professor, University of Innsbruck, Austria

Massimo Santoro, PhD

EMBO Fellowshp

HFSP Fellowship

Assistant Professor, University of Turino, Italy

Wiebke Herzog, PhD

DFG Fellowship

AHA Fellowship

Junior Group Leader, MPI Muenster, Germany

Paul Scherz, PhD

Helen Hay Whitney Fellowship

Student, University of Notre Dame, IN

Michel Bagnat, PhD

EMBO Fellowship

Assistant Professor, Duke University Medical Center, Durham, NC

Duc Dong, PhD

JDRF Fellowship

Hillblom Fellowship

Assistant Professor, Burnham Institute, San Diego, CA

Neil Chi, MD, PhD

AHA Fellow to Faculty Award

NIH K08 Grant

Assistant Professor, UC San Diego, CA

Lingfei Luo, PhD

JDRF Senior Postdoctoral Fellowship

Assistant Professor, Southwest University, China

Silvia Curado, PhD

CVRI Fellowship

Program Manager, New York University, NY

Jan Huisken, PhD

HFSP Fellowship

Junior Group Leader, MPI Dresden, Germany

Takuya Sakaguchi, PhD

APS Fellowship

NIH K99 Grant

Assistant Professor, Cleveland Clinic, Cleveland, OH

Ryan Anderson, PhD

JDRF Fellowships

Assistant Professor, Indiana University School of

Medicine, Indianapolis, IN

Chong Shin, PhD

NIH NRSA Fellowship

NIH K01 Grant

Assistant Professor, Georgia Institute of Technology, Atlanta, GA

Donghun Shin, PhD

JDRF Fellowship

Assistant Professor, University of Pittsburgh Medical School, Pittsburgh, PA

Amnon Schlegel, MD, PhD

NIH K08 Grant

Assistant Professor, University of Utah Medical School, Salt Lake City, UT

 

Special students and other lab visitors (partial list since 2005)

2005

Jessica Ahlsiö, visiting Ph.D. student from Lund University, Sweden

2005

Joaquin Grego Bessa, visiting Ph.D. student from Madrid, Spain

2005-2006

Rima Arnaout, Sarnoff fellow from Harvard Medical School

2005-2006

Colin Lorentzen, Diana Kuo, UCB undergraduates

2006

Guillaume Gibon, visiting master’s student from Paris, France

2006

Pankaj Sahai, SRTP student from the University of Puerto Rico

2006, 2007

Linda Setiawan, visiting Diploma student from Freie Universitaet Berlin

2006

Frederic Marteau, Ph.D., sabbatical scientist from the Universite libre de Bruxelles

2007

Emmanuelle Szenker, visiting master’s student from Paris, France

2007

Gabriella Pesce, visiting postdoctoral fellow from University of Piemonte, Italy

2007

Nik Tomanovic, visiting student from Cambridge University, UK

2008

Marine Beinat, visiting master’s student from Paris, France

2009

Julie Prudhomme, visiting master’s student from Paris, France

2010

Laetitia Lemeray, visiting master’s student from Paris, France

2010

Philbert Lee, SFSU master’s student, CIRM Bridges grantee

2010

Jennifer Hampton, Humboldt State University master’s student, CIRM Bridges grantee

2010

Naoki Tsuji, Ph.D., visiting scientist from Daiichi-Sankyo Co., Tokyo, Japan

 

 

Faculty Mentoring: Darren Schneider (KO8 mentor), Miguel Ramalho-Santos, Pao-Tien Chuang, Jeremy Reiter, David Bilder (UCB), Maria Barna, Ross Metzger.  I have read and critiqued grant applications and manuscripts.  I have also offered advice and feedback re various scientific and academic growth matters.

 

Teaching Award:

2003

Outstanding Faculty Mentorship Award, UCSF

 

PEER REVIEWED RESEARCH ARTICLES

*indicates 12 most significant publications

 

1.      Stainier, D.Y.R. and Gilbert, W. (1989).  The monoclonal antibody B30 recognizes a specific neuronal cell surface antigen in the developing mesencephalic trigeminal nucleus of the mouse.  J. Neurosci. 9: 2468-2485.

 

2.      Stainier, D.Y.R. and Gilbert, W. (1990).  Pioneer neurons in the mouse trigeminal sensory system.  Proc. Natl. Acad. Sci. USA 87: 923-927.

 

3.      Stainier, D.Y.R. and Gilbert, W. (1991).  Neuronal differentiation and maturation in the mouse trigeminal sensory system, in vivo and in vitro.  J. Comp. Neurol.  311: 300-312.

 

4.      Stainier, D.Y.R., Bilder, D.H. and Gilbert, W (1991). The B30 ganglioside is a cell surface marker for neural crest-derived neurons in the developing mouse.  Developmental Biology 144: 177-188.

 

5.      Stainier, D.Y.R., Bilder, D.H. and Gilbert, W (1991).  Spatial domains in the developing forebrain: developmental regulation of a restricted cell surface protein.  Developmental Biology 147: 22-31.

 

6.      Stainier, D.Y.R. and Fishman, M.C. (1992).  Patterning the zebrafish heart tube: acquisition of anteroposterior polarity.  Developmental Biology 153: 91-101.

 

7.      Stainier, D.Y.R., Lee, R.K. and Fishman, M.C. (1993).  Cardiovascular development in the zebrafish: I. Myocardial fate map and heart tube formation.  Development 119: 31-40.

 

8.      Abdelilah, S., Solnica-Krezel, L., Stainier, D.Y.R. and Driever, W. (1994).  Implications for dorsoventral axis determination from the zebrafish mutation janus.  Nature 370: 468-471.

 

9.      Lee, R.K.K., Stainier, D.Y.R., Weinstein, B.W. and Fishman, M.C. (1994).  Cardiovascular development in the zebrafish:  II.  Endocardial progenitors are sequestered within the heart field.   Development 120: 3361-3366.

 

10.     Stainier, D.Y.R., Weinstein, B.M.W., Detrich H.W., Zon, L.I. and Fishman, M.C. (1995). cloche, an early acting zebrafish gene, is required by both the endothelial and hematopoietic lineages.  Development 121, 3141-3150.

 

11.     Driever, W., Solnica-Krezel, L., Schier, A.F., Neuhauss, S.C.F., Malicki, J., Stemple, D.L., Stainier, D.Y.R., Zwartkruis, F., Abdelilah, S., Rangini, Z., Belak, J. and Boggs, C. (1996).  A genetic screen for mutations affecting embryogenesis in zebrafish.  Development 123:37-46.

 

12.     Solnica-Krezel, L., Stemple, D. L., Mountcastle-Shah, E., Rangini, Z., Neuhauss, S. C. F., Malicki, J., Schier, A. F., Stainier, D. Y. R., Zwartkruis, F., Abdelilah, S. and Driever, W. (1996).   Mutations affecting cell fates and cellular rearrangements during gastrulation in zebrafish.  Development 123: 67-80.

 

13.     Stemple, D. L., Solnica-Krezel, L., Zwartkruis, F., Neuhauss, S. C. F., Schier, A. F., Malicki, J., Stainier, D. Y. R., Abdelilah, S., Rangini, Z., Mountcastle-Shah, E. and Driever, W. (1996).  Mutations affecting development of the notochord in zebrafish.  Development 123: 117-128S

 

14.     Schier, A. F., Neuhauss, S. C. F., Harvey, M., Malicki, J., Solnica-Krezel, L., Stainier, D. Y. R., Zwartkruis, F., Abdelilah, S., Stemple, D. L., Rangini, Z., Yang, H. and Driever, W. (1996).  Mutations affecting the development of the embryonic zebrafish brain.  Development 123: 165-178.

 

15.     Abdelilah, S., Mountcastle-Shah, E., Harvey, M., Solnica-Krezel, L., Schier, A. F., Stemple, D. L., Malicki, J., Neuhauss, S. C. F., Zwartkruis, F., Stainier, D. Y. R., Rangini, Z. and Driever, W. (1996).  Mutations affecting neural survival in the zebrafish, Danio rerio.  Development 123:217-227.

 

16.     Malicki, J., Neuhauss, S. C. F., Schier, A. F., Solnica-Krezel, L., Stemple, D. L., Stainier, D. Y. R., Abdelilah, S., Zwartkruis, F., Rangini, Z. and Driever, W. (1996).  Mutations affecting development of the zebrafish retina.  Development 123: 263-273.

 

17.     Malicki, J., Schier, A. F., Solnica-Krezel, L., Stemple, D. L., Neuhauss, S. C. F., Stainier, D. Y. R., Abdelilah, S., Rangini, Z., Zwartkruis, F. and Driever, W. (1996).  Mutations affecting development of the zebrafish ear.  Development 123: 275-283.

 

18.     Stainier, D. Y. R., Fouquet, B., Chen, J.-N., Warren, K. S., Weinstein, B. M., Meiler, S., Mohideen, M.-A. P. K., Neuhauss, S. C. F., Solnica-Krezel, L., Schier, A. F., Zwartkruis, F., Stemple, D. L., Malicki, J., Driever, W. and Fishman, M. C. (1996).  Mutations affecting the formation and function of the cardiovascular system in the zebrafish embryo.  Development 123:285-292.

 

19.     Weinstein, B. M., Schier, A. F., Abdelilah, S., Malicki, J., Solnica-Krezel, L., Stemple, D. L., Stainier, D. Y. R., Zwartkruis, F., Driever, W. and Fishman, M. C. (1996).  Hematopoietic mutations in the zebrafish.  Development 123: 303-309.

 

20.     Neuhauss, S. C. F., Solnica-Krezel, L., Schier, A. F., Zwartkruis, F., Stemple, D. L., Malicki, J., Abdelilah, S., Stainier, D. Y. R. and Driever, W. (1996).  Mutations affecting craniofacial development in zebrafish.  Development 123: 357-367.

 

21.     Ticho, B.S., Stainier, D.Y.R., Fishman, M.C. and Breitbart, R.E. (1996).  Three zebrafish MEF2 genes delineate somitic and cardiac muscle development in wild-type and mutant embryos.  Mechanisms of Development 59:205-218.

 

22.     Liao, W., Bisgrove, B.W., Sawyer, H., Hug, B., Bell, B., Peters, K., Grunwald, D.J. and Stainier, D.Y.R. (1997).  The zebrafish gene cloche acts upstream of a flk-1 homologue to regulate endothelial cell differentiation.  Development 124: 381-389.

 

23.     Alexander, J., Stainier, D.Y.R. and Yelon, D. (1998).  Screening mosaic F1 females for mutations affecting zebrafish heart induction and patterning.  Developmental Genetics 22: 288-299.  D.Y.R.S. senior author.

 

24.     Lyons, M.S., Bell, B., Stainier, D.Y.R. and Peters, K. (1998).  Isolation of the zebrafish homologues for the tie-1 and tie-2 endothelium specific receptor tyrosine kinases.  Developmental Dynamics 212: 133-140.

 

25.     Haun, C., Alexander, J., Stainier, D.Y.R. and Okkema, P.G. (1998).  Rescue of C. elegans pharyngeal development by a vertebrate heart specification gene.  Proc. Natl. Acad. Sci. USA 95: 5072-5075.

 

26.     Reifers, F., Bohli, H., Walsh, E.C., Stainier, D.Y.R. and Brand, M. (1998).  Fgf8 is mutated in zebrafish acerebellar mutants and is required for maintenance of midbrain-hindbrain boundary development and somitogenesis.  Development 125: 2381-2395.

 

27.     Karlovich, C.A., John, R., Ramirez, L., Stainier, D.Y.R. and Myers, R.M. (1998).  Characterization of the Huntington disease (HD) gene homolog in the zebrafish Danio rerio.  Gene 217: 117-125.

 

28.     Parker, L.H. and Stainier, D.Y.R. (1999).  Cell-autonomous and non-autonomous requirements for the zebrafish gene cloche in hematopoiesis.  Development 126: 2643-2651.

 

29.     Yelon, D., Horne, S.A. and Stainier, D.Y.R. (1999).  Restricted expression of cardiac myosin genes reveals regulated aspects of heart tube assembly in zebrafish.  Developmental Biology 214: 23-37.

 

30.     Alexander, J., Rothenberg, M., Henry, G.L. and Stainier, D.Y.R. (1999).  casanova plays an early and essential role in endoderm formation in zebrafish.  Developmental Biology 215: 343-357.

 

31.     Ho, C.Y., Houart, C., Wilson, S.W., and Stainier, D.Y.R. (1999).  A role for the extraembryonic yolk syncytial layer in patterning the zebrafish embryo suggested by properties of the Hex gene.  Current Biology 9: 1131-1134.

 

*32.   Alexander, J. and Stainier, D.Y.R. (1999).  A molecular pathway leading to endoderm formation in zebrafish.  Current Biology 9: 1147-1157.  See Commentary in Current Biology 9: R812-815.

 

33.     Reiter, J., Alexander, J., Rodaway, A., Yelon, D. Patient, R., Holder, N. and Stainier, D.Y.R. (1999).  Gata5 is required for the development of the heart and endoderm in zebrafish.  Genes & Development 13: 2983-2995.

 

34.     Reifers, F., Walsh, E., Leger, S., Stainier, D.Y.R. and Brand, M. (2000).  Induction and differentiation of the zebrafish heart requires Fgf8.  Development 127: 225-235.

 

35.         Griffin, K.J.P., Stoller, J., Gibson, M., Chen, S., Yelon, D., Stainier, D.Y.R. and Kimelman, D. (2000).  A conserved role for H15-related T-box transcription factors in zebrafish and Drosophila heart formation.  Developmental Biology 218: 235-247.

 

36.     Kikuchi, Y., Trinh, L., Reiter, J.F., Alexander, A., Yelon, D. and Stainier, D.Y.R. (2000).  The zebrafish bonnie and clyde gene encodes a Mix family homeodomain protein that regulates the generation of endodermal precursors.  Genes & Development 14: 1279-1289.

 

37.         Yelon, D., Ticho, B, Halpern, M., Ruvinsky, I., Ho, R., Silver, L.M. and Stainier, D.Y.R. (2000).  The bHLH transcription factor Hand2 plays parallel roles in zebrafish heart and pectoral fin development.  Development 127: 2573-2582.  See Commentary in Nature 406, 953-954.

 

*38.   Kupperman, E., An, S., Osborne, N., Waldron, S. and Stainier, D.Y.R. (2000).  A sphingosine 1-phosphate receptor regulates cell migration during vertebrate heart development.  Nature 406: 192-195. 

         See Commentaries in Nature 406, 141-142 and in Science 289, 509.

 

39.     Liao, W., Ho, C.-H., Yan, Y.L., Postlethwait, J. and and Stainier, D.Y.R. (2000).  Hhex and Scl function in parallel to regulate early endothelial and blood differentiation in zebrafish.  Development 127: 4303-4313.

 

40.         Motoike, T., Loughna, S., Perens, E. Roman, B.L., Liao, W., Chau, T.C., Richardson, C.D., Kawate, T., Kuno, J., Weinstein, B.M, Stainier, D.Y.R. and Sato, T.N. (2000). Universal GFP Reporter for the Study of Vascular Development.  Genesis 28: 75-81.

 

41.         Reiter, J.F, Kikuchi, Y. and Stainier, D.Y.R. (2001).  Multiple roles for Gata5 in zebrafish endoderm formation.  Development 128: 125-135.

 

42.         Reiter, J.F., Verkade, H. and Stainier, D.Y.R. (2001).  Bmp2b and Oep promote early myocardial differentiation through their regulation of gata5.  Developmental Biology 234: 330-338.

 

43.     Kikuchi, Y., Agathon, A., Alexander, J., Thisse, C., Waldron, S., Yelon, D., Thisse, B. and Stainier,

D.Y.R. (2001).  casanova encodes a novel Sox-related protein necessary and sufficient for early endoderm formation in zebrafish.  Genes & Development 15: 1493-1505.

 

*44.   Walsh, E.C. and Stainier, D.Y.R. (2001).  UDP-glucose dehydrogenase required for cardiac valve formation in zebrafish.  Science 293: 1670-1673.  Highlighted in Faculty of 1000.

 

45.     Horne-Badovinac, S., Lin, D., Waldron, S., Schwartz, M. Pawson, A., Jan, Y.N., Stainier, D.Y.R. and Abdelilah-Seyfried, S. (2001).  Positional cloning of heart and soul reveals multiple roles for PKCl in zebrafish organogenesis.  Current Biology 11:1492-1502.  D.Y.R.S. senior author.

 

46.     Keegan, B.R., Feldman, J.L., Lee, D.H., Koos, D.S., Ho, R.K., Stainier, D.Y.R. and Yelon D. (2002).  The elongation factors Pandora/Spt6 and Foggy/Spt5 promote transcription in the zebrafish embryo.  Development 129: 1623-1632.

 

47.     Sehnert, A., Huq, A., Weinstein, B., Fishman, M.C. and Stainier, D.Y.R. (2002). Cardiac Troponin T plays

         essential roles in sarcomere assembly and cardiac contractility.  Nature Genetics 31: 106-110.

 

48.     The Ciona genome consortium (Dehal et al.) (2002).  The draft genome of Ciona intestinalis: insights into chordate and vertebrate origins.  Science 298: 2157-2167.

 

49.     Field, H., Ober, E.A., Roeser, T. and Stainier, D.Y.R. (2003).  Formation of the digestive system in zebrafish: I. Liver morphogenesis.  Developmental Biology 253: 279-290.

 

50.     Miller, C.T., Yelon, D., Stainier, D.Y.R. and Kimmel, C.B. (2003).  Two endothelin1 effectors, Hand2 and Bapx1, pattern ventral pharyngeal cartilage and the jaw joint.  Development 130:1353-1365.

 

51.     Field, H.A., Dong, P.D.S., Beis, D. and Stainier, D.Y.R. (2003).  Formation of the digestive system in zebrafish: II. Pancreas morphogenesis.  Developmental Biology 261: 197-208.

 

52.     Trinh, L.A., Meyer D. and Stainier, D.Y.R. (2003).  The Mix family homeodomain gene bonnie and clyde functions with other components of the Nodal signaling pathway to regulate neural patterning in zebrafish.  Development 130: 4989-4998.

 

53.     Tidyman, W.E., Sehnert, A.J., Huq, A., Agard, J., Deegan, F., Stainier, D.Y.R. and Ordahl, C.P. (2003).  In vivo regulation of the chicken cardiac troponin T gene promoter in zebrafish.  Dev. Dyn. 227:

         484-496.

 

*54.   Horne-Badovinac, S., Rebagliati, M. and Stainier, D.Y.R. (2003).  A cellular framework for gut looping morphogenesis in zebrafish.  Science 302: 662-665.  Highlighted in Faculty of 1000.

 

55.     Berdougo, E., Coleman, H., Lee, D.H., Stainier, D.Y.R. and Yelon, D. (2003).  Mutation of weak atrium/atrial myosin heavy chain disrupts atrial function and influences ventricular morphogenesis in zebrafish. Development 130: 6121-6129.

 

56.     Ober, E.A., Olofsson, B., Makinen, T., Jin, S.-W., Shoji, W., Koh, G.Y., Alitalo, K. and Stainier, D.Y.R. (2004).  Vegfc is required for vascular development and endoderm morphogenesis in zebrafish.  EMBO reports 5: 78-84. 

 

57.    Reim, G., Mizoguchi, T., Stainier, D.Y., Kikuchi, Y. and Brand, M. (2004).  The POU domain protein Spg (Pou2/Oct4) is essential for endoderm formation in cooperation with the HMG domain protein Casanova.  Dev. Cell 6: 91-101.  Highlighted in Faculty of 1000.

 

58.    Trinh, L.A. and Stainier, D.Y.R. (2004). Fibronectin regulates epithelial organization during myocardial

         migration in zebrafish.  Dev. Cell 6: 371-382.  Highlighted in Faculty of 1000.

 

59.    Parker, L.H., Schmidt, M., Jin, S.-W., Gray, A.M., Beis, D., Pham, T., Frantz, G., Palmieri, S., Hillan, K., Stainier, D.Y.R., de Sauvage, F.J., Ye, W. (2004).  A novel endothelial cell derived secreted factor VEMF regulates vascular tube formation.  Nature 428: 754-758.

 

60.    Kikuchi, Y., Verkade, H., Reiter, J.F., Kim, C.-H., Chitnis, A.B., Kuroiwa, A. and Stainier, D.Y.R. (2004).  Notch signaling can regulate endoderm formation in zebrafish. Dev. Dyn. 229: 756-762.

 

61.    Bartman, T., Walsh, E.C., Wen, K.-K., McKane, M., Ren, J., Alexander, J., Rubenstein, P.A. and Stainier, D.Y.R.  (2004).  Early Myocardial Function Affects Endocardial Cushion Development in Zebrafish.  PLoS Biology 2: 673-681.

 

62.    Trinh, L.A., Yelon, D. and Stainier, D.Y.R. (2005).  Hand2 regulates epithelial formation during myocardial differentiation.  Current Biology 15: 441-446.

 

63.    Qian, F., Zhen, F., Ong, C., Jin, S.-W., Soo, M.H., Stainier, D.Y.R., Lin, S., Peng, J. and Wen, Z. (2005).  Microarray analysis of zebrafish cloche mutant using amplified cDNA and identification of potential downstream target genes.  Dev. Dyn. 233: 1163-1172.

 

64.    Bree, R.T., McLoughlin, S., Jin, S.-W., McMeel, O.M., Stainier, D.Y.R., Grealy, M. and Byrnes, L. (2005).  nanor, a novel zygotic gene, is expressed initially at the midblastula transition in zebrafish.  Biochem. Biophys. Res. Commun. 333: 722-728.

 

65.     Ng, A.N.Y., de Jong-Curtain, T.A., White, S.J., Mawdsley, D.J., Shin, J., Appel, B., Dong P.D.S., Stainier, D.Y.R. and Heath, J.K. (2005).  Formation of the digestive system in zebrafish.  III. Intestinal epithelium morphogenesis. Developmental Biology 286, 114-135.

 

66.     Beis, D., Bartman, T., Jin, S.-W., Scott, I.C., D’Amico, L., Ober, E.A., Verkade, H., Frantsve, J., Field,

         H.A., Wehman, A., Baier, H., Talafuss, A., Bally-Cuif, Chen, J.-N., Stainier, D.Y.R. and Jungblut, B.

         (2005).  Genetic and cellular analyses of zebrafish atrio-ventricular cushion and valve development. 

Development 132: 4193-4204.  D.Y.R.S. senior author.

 

67.     Jin, S.-W, Beis, D., Mitchell, T., Chen, J.-N. and Stainier, D.Y.R. (2005).  Cellular and molecular analyses of vascular tube and lumen formation in zebrafish. Development 132: 5199-209. 

 

68.     Corbit, K.C., Aanstad, P., Singla, V., Norman, A.R., Stainier, D.Y.R. and Reiter, J.F. (2005).  Vertebrate

         Smoothened functions at the primary cilium.  Nature 437: 1018-1021.

 

*69.   Ober, E.A., Verkade, H., Field, H.A. and Stainier, D.Y.R. (2006).  Mesodermal Wnt2b signaling positively regulates liver specification.  Nature 442: 688-691.  Highlighted in Nature Genetics, Nature Cell Biology, Faculty of 1000 and Current Biology.

 

*70.   Vogeli, K.M., Jin, S.-W., Martin, G.R. and Stainier, D.Y.R. (2006).  A common progenitor for hematopoietic and endothelial lineages in the zebrafish gastrula.  Nature 443: 337-339.  Highlighted in Faculty of 1000.

 

71.     Sakaguchi, T., Kikuchi, Y., Kuroiwa, A., Takeda, H. and Stainier, D.Y.R. (2006).  The yolk syncytial layer regulates myocardial migration by influencing extracellular matrix assembly in zebrafish.  Development 133: 4063-4072.

 

72.     Schlegel, A. and Stainier, D.Y.R. (2006).  Microsomal triglyceride transfer protein is required for yolk lipid utilization and absorption of dietary lipids in zebrafish larvae.  Biochemistry 45: 15179-15187.

 

73.     D’Amico, L., Scott, I.C., Jungblut, B. and Stainier, D.Y.R. (2007).  A mutation in zebrafish hgmcr1b reveals a role for isoprenoids in vertebrate heart tube formation.  Current Biology 17: 252-259.

 

74.     Dong, P.D.S., Munson, C., Norton, W., Crosnier, C., Pan, X., Gong, Z., Neumann, C.J. and Stainier, D.Y.R. (2007).  Fgf10 regulates hepatopancreatic ductal system patterning and differentiation.  Nature Genetics 39: 397-402.

 

75.     Curado, S., Anderson, R.M., Jungblut, B., Mumm, J., Schroeter, E. and Stainier, D.Y.R. (2007). 

         Conditional targeted cell ablation in zebrafish: A new tool for regeneration studies.  Developmental

         Dynamics 236: 1025-35.

 

76.     Scott, I.C., Masri, B., D’Amico, L., Jin, S.-W., Jungblut, B., Wehman, A., Baier, H., Audigier, Y. and Stainier, D.Y.R. (2007).  The G protein-coupled receptor Agtrl1b regulates early development of myocardial progenitors.  Developmental Cell 12: 403-413.  Highlighted in Developmental Cell and Cell.

 

77.     Shin D., Shin C.H., Tucker J., Ober E.A., Rentzsch F., Poss K.D., Hammerschmidt M., Mullins M.C. and Stainier D.Y.R. (2007).  Bmp and Fgf signaling are essential for liver specification in zebrafish. Development 134: 2041-2050.

 

78.     Jin, S.W., Herzog, W., Santoro, M.M., Mitchell, T.S., Frantsve, J., Jungblut, B., Beis, D., Scott, I.C., D'Amico, L.A., Ober, E.A., Verkade, H., Field, H.A., Chi, N.C., Wehman, A.M., Baier, H., and Stainier, D.Y.R. (2007) A transgene-assisted genetic screen identifies essential regulators of vascular development in vertebrate embryos. Developmental Biology 307: 29-42.

 

79.     Arnaout, R., Ferrer, T., Huisken, J., Spitzer, K., Stainier, D.Y.R., Tristani-Firouzi, M., and Chi, N.C. (2007) Zebrafish model for human long QT syndrome. Proc. Natl. Acad. Sci. USA 104: 11316-11321.        †corresponding authors.

 

*80.   Bagnat, M., Cheung, I.D., Mostov, K.E. and Stainier D.Y.R. (2007).  Genetic control of single lumen formation in the zebrafish gut.  Nature Cell Biology 9: 954-960.  Highlighted in Nature Cell Biology, J, Cell Biology, Faculty of 1000 and Nature Reviews Genetics.

 

81.     Huisken, J. and and Stainier D.Y.R. (2007).  Even fluorescence excitation by multi-directional selective plane illumination microscopy (mSPIM). Optics Letters 32: 2608-2610.

 

82.     Santoro, M.M., Samuel, T., Mitchell, T.S., Reed, J.C. and Stainier D.Y.R. (2007). Birc2/Iap1 regulates endothelial cell integrity and blood vessel homeostasis.  Nature Genetics 39: 1397-1402.  Highlighted in Nature Genetics.

 

83.     Scherz, P.J., Huisken J., Sahai-Hernandez, P. and Stainier D.Y.R. (2008).  High speed imaging of developing heart valves reveals interplay of morphogenesis and function.  Development 135: 1179-1187.

 

84.     Chi, N.C, Shaw R.M., De Val, S., Kang, G., Jan, L.Y., Black B.L. and Stainier D.Y.R. (2008).  Foxn4 directly regulates tbx2b expression and atrioventricular canal formation. Genes & Development 22: 734-9.

 

*85.   Chi, N.C., Shaw R.M., Jungblut, B., Huisken J., Arnaout, R., Scott, I.C., Beis, D., Ferrer, T., Xiao, T., Baier, H., Jan, L.Y., Tristani-Firouzi, M. and Stainier D.Y.R. (2008).  Genetic and physiologic dissection of the vertebrate cardiac conduction system.  PLoS Biology 6: 1006-1019.

 

*86.   Chung, W-S. and Stainier D.Y.R. (2008).  Intra-endodermal interactions are required for pancreatic b-cell induction.  Developmental Cell 14: 582-593.  Highlighted in Faculty of 1000.

 

87.     Curado, S., Stainier, D.Y.R. and Anderson, R.M. (2008). Nitroreductase-mediated cell/tissue ablation in zebrafish: a spatially and temporally controlled ablation method with applications in developmental and regeneration studies.  Nature Protocol 3: 948-954. D.Y.R.S. senior author.

 

88.     Shin C.H., Chung, W-S., Hong S-K., Ober E.A., Verkade, H., Field, H., Huisken, J. and Stainier D.Y.R. (2008).  Multiple roles for Med12 in vertebrate endoderm development.  Developmental Biology, 317: 467-479.

 

89.     Dong, P.D.S., Provost, E., Leach S.D. and Stainier, D.Y.R. (2008).  Graded levels of Ptf1a differentially regulate endocrine and exocrine fates in the developing pancreas. Genes & Development 22: 1445-1450.

 

90.     Bit-Avragim, N., Hellwig, N., Rudolph, F., Munson, C., Stainier, D.Y.R., and Abdelilah-Seyfried, S. (2008).  Divergent polarization mechanisms during vertebrate epithelial development mediated by the Crumbs complex protein Nagie oko. J. Cell Sci. 121: 2503-2510.

 

91.     Fish, J.E., Santoro, M.M., Morton, S.U., Yu, S., Yeh, R.F., Wythe, J.D., Ivey, K.N., Bruneau, B.G., Stainier D.Y.R. and Srivastava, D. (2008).  miR-126 regulates angiogenic signaling and vascular integrity. Developmental Cell 15: 271-284.   

 

92.     Morton, S.U., Scherz, P.J., Cordes, K.R., Ivey, K.N., Stainier D.Y.R. and Srivastava, D. (2008).  microRNA regulation of cardiac patterning. Proc. Natl. Acad. Sci. USA 105: 17830-5.

 

93.     Sakaguchi, T.F., Sadler, K.C., Crosnier, C. and Stainier, D.Y.R. (2008).  Endothelial signals modulate hepatocyte apico-basal polarization in zebrafish.  Current Biology 18: 1565-1571. 

 

94.     De Val, S., Chi, N.C, Meadows, S.M., Minovitsky, S., Anderson, J., Harris, I.A., Ehlers, M.L., Agarwal, P., Visel, A., Xu, S.-M., Pennacchio, L.A., Dubchak, I., Krieg, P.A., Stainier D.Y.R. and Black B.L. (2008).  A Forkhead-Ets transcription factor code for vascular development.  Cell 135: 1053-1064.  Highlighted in Faculty of 1000.

 

95.     Munson, C., Huisken, H., Bit-Avragim, N., Kuo, T., Dong, P.D., Ober E.A., Verkade, H., Abdelilah-Seyfried, S. and Stainier, D.Y.R. (2008).  Regulation of neurocoel morphogenesis by Pard6gb. Developmental Biology 324: 41-54.

 

96.     Chung, W-S., Shin, C.H. and Stainier D.Y.R. (2008).  Bmp2 signaling regulates the hepatic vs pancreatic fate decision.  Developmental Cell 15: 738-748.  Highlighted in Faculty of 1000.

 

*97.   Osborne, N., Brand-Arzamendi, K., Ober E.A., Jin, S.W., Verkade, H., Holtzman, N.G., Yelon, D. and Stainier, D.Y.R. (2008).  The Spinster homologue, Two of hearts, is required for sphingosine 1-phosphate signaling in zebrafish.  Current Biology 18: 1882-1888.  Highlighted in Science.

 

98.     de Jong-Curtain, T.A., Parslow, A.C., Trotter, A.J., Hall, N.E., Verkade, H., Tabone, T., Christie, E.L., Crowhurst, M.O., Layton, J.E., Shepherd, I.T., Nixon, S.J., Parton, R.G., Zon, L.I., Stainier, D.Y.R., Lieschke, G.J., Heath, J.K. (2008).  Abnormal Nuclear Pore Formation Triggers Apoptosis in the Intestinal Epithelium of elys-Deficient Zebrafish.  Gastroenterology 136: 902-911.

 

99.     Aanstad, P., Santos, N., Corbit, K.C., Scherz, P.J., Trinh, L.A., Salvenmoser, W., Huisken, J., Reiter, J.F. and Stainier, D.Y.R. (2009).  The extracellular domain of Smoothened regulates ciliary localisation and is required for high level Hh signaling. Current Biology 19: 1034-1039.

 

100.   Goll, M.G., Anderson, R.M., Stainier, D.Y.R., Spradling, A.C. and Halpern, M.E. (2009).  Transcriptional silencing and reactivation in transgenic zebrafish.  Genetics 182: 747-755.

 

101.   Herzog, W., Muller, K., Huisken, J. and Stainier, D.Y.R. (2009).  Genetic evidence for a noncanonical function of Seryl-tRNA synthetase in vascular development.  Circulation Research, 104: 1260-1266.

 

102.   Santoro, M.M., Pesce, G. and Stainier, D.Y.R. (2009).  Characterization of vascular mural cells during zebrafish development.  Mech. Dev. 126: 638-649.  Highlighted in Faculty of 1000.

 

103.   Anderson, R.M., Bosch, J.A., Goll, M.G., Hesselson, D., Dong, P.D.S., Shin D., Chi, N.C., Shin C.H., Schlegel, A., Halpern, M.E. and Stainier, D.Y.R. (2009).  Loss of Dnmt1 catalytic activity reveals multiple roles for DNA methylation during pancreas development and regeneration.  Developmental Biology 334: 213-223.

 

104.   Hesselson, D., Anderson, R.M., Beinat, M. and Stainier, D.Y.R. (2009).  Distinct populations of quiescent and proliferative pancreatic β-cells identified by HOTcre mediated labeling. Proc. Natl. Acad. Sci. USA 106: 14896-14901.  Highlighted in Faculty of 1000.

 

105.   Lee, C.Y., Vogeli, K.M., Kim, S-H., Chong S-W., Jiang Y-J., Stainier, D.Y.R. and Jin, S-W. (2009).  Notch Signaling Functions as a Cell Fate Switch Between the Endothelial and the Hematopoietic Lineages. Current Biology 19: 1616-1622.

 

*106. Herbert, S.P., Huisken, J., Kim, T.N., Feldman, M.E., Houseman, B.T., Wang, R.A., Shokat, K.M. and Stainier, D.Y.R. (2009).  Arterial/Venous Segregation by Selective Cell Sprouting: An Alternative Mode of Blood Vessel Formation.  Science 326: 294-298. Highlighted in Science, Faculty of 1000.

 

107.   Smyth, J.W., Hong, T.-T., Gao, D., Vogan, J., Jensen, B.C., Fong, T.S., Simpson, P.C., Stainier, D.Y.R., Chi, N.C. and Shaw, R.M. (2009).  Limited forward trafficking of Connexin43 reduces cell-cell coupling in stressed myocardium.  J. Clin. Invest. 120: 266-279. Highlighted in Faculty of 1000.

 

108.   Chung, W-S., Andersson, O., Row, R., Kimelman, D. and Stainier D.Y.R. (2010).  Suppression of Alk8-mediated Bmp signaling cell-autonomously induces pancreatic β-cells.  Proc. Natl. Acad. Sci. USA 107: 1142-1147.

 

109.   Bertrand, J.Y., Chi, N.C., Santoso, B., Teng, S., Stainier D.Y.R. and Traver D. (2010).  Hematopoietic stem cells derive directly from aortic endothelium during development.  Nature 464: 108-111.  Highlighted in Faculty of 1000.

 

110.   Kikuchi, K., Holdway, J.E., Werdich, A.A., Anderson, R. M., Fang, Y., Egnaczyk, G.F., Evans, T., MacRae, C.A., Stainier D.Y.R. and Poss, K.D. (2010).  Primary contribution to zebrafish heart regeneration by Gata4+ cardiomyocytes.  Nature 464: 601-605. Highlighted in Circulation Research.

 

111.   Curado, S., Ober, E.A., Walsh, S., Cortes-Hernandez, P., Verkade, H., Koehler, C.M. and Stainier D.Y.R. (2010).  The mitochondrial import gene tomm22 is specifically required for hepatocyte survival and provides a liver regeneration model.  Disease Models and Mechanisms 3, 486-495.

 

112.   Liu, J. and Stainier D.Y.R. (2010).  Tbx5 and Bmp signaling are essential for proepicardium specification in zebrafish. Circulation Research 106:1818-1828.

 

113.   Yin, C., Kikuchi, K., Hochgreb, T., Poss, K.D. and Stainier D.Y.R. (2010).  Hand2 regulates extracellular matrix remodeling essential for gut-looping morphogenesis in zebrafish. Developmental Cell 18, 973-984.

 

114.   Chi, N.C., Bussen, M., Brand-Arzamendi, K., Ding, C., Olgin, J.E., Shaw R.M., Martin, G.R. and Stainier D.Y.R. (2010).  Cardiac conduction is required to preserve cardiac chamber morphology.  Proc. Natl. Acad. Sci. USA 107, 14662-14667.  Highlighted in Nature.

 

115.   Bagnat, M., Navis, A., Herbstreith, S., Brand-Arzamendi, K., Curado, S., Gabriel, S., Mostov, K.,

         Huisken, J and Stainier D.Y.R. (2010).  Cse1l is a negative regulator of CFTR-dependent fluid secretion. 

         Current Biology 20, 1840-1845.

 

116.   Liu, J., Bressan, M., Hassel, D., Huisken, J., Staudt, D., Kikuchi, K., Poss, K.D., Mikawa, T. and

      Stainier, D.Y.R. (2010).  A dual role for ErbB2 signaling in cardiac trabeculation.  Development 137, 3867-3875.

 

*117. Arrenberg, A.B., Stainier, D.Y.R., Baier, H. and Huisken, J. (2010).  Optogenetic control of cardiac             function.  Science 330, 971-974. D.Y.R.S. senior author. Highlighted in Nature.

 

118.   Kalousova, A., Mavropoulos, A., Adams, B.A., Nekrep, N., Li, Z., Krauss, S., Stainier, D.Y.R. and

         German, M. (2010).  Dachshund homologues play a conserved role in islet cell development. 

         Developmental Biology 348, 143-152.

 

119.   Jurczyk, A., Roy, N., Bajwa, R., Gut, P., Lipson, K., Yang, C., Covassin, L., Racki, W.J., Rossini,

         A.A., Philips, N., Stainier, D.Y.R., Grenier, D.L., Brehm, M.A., Borteli, R. and DiIorio, P. (2011).

         Dynamic glucoregulation and mammalian-like responses to metabolic and developmental disruption in

         zebrafish.  Gen Comp Endocrinol 170, 334-345.

 

120.   Tittle, R., Sze, R., Ng, A., Nuckels, R.J., Swartz, M.E., Anderson, R.M., Bosch, J., Stainier, D.Y.R., Eberhart, J.K. and Gross, J.M. (2011).  Uhrf1 and Dnmt1 are required for development and maintenance of the zebrafish lens.  Developmental Biology 350, 50-63.

 

121.  Takeuchi, J.K., Togi, K., Lou, X., Alexander, J., Delgado-Olguin, P., Holloway, A., Mori, A., Munson, C., Wylie, J., Sukonnik, T., Kaynak, B., Zhu, Y., Yuqing, Z., Yeh, R., Henkelman, M., Harvey, R., Izumo, S., Metzger, D., Chambon, P., Stainier, D.Y.R., Pollard, K., Scott, I.C. and Bruneau, B.G. (2011).  Chromatin Remodeling Complex Dosage Modulates Transcription Factor Function in Cardiogenesis and Congenital Heart Disease.  Nature Communications 2, 187.

 

122.  Shin, D., Lee, Y. Poss, K.D. and Stainier D.Y.R. (2011).  Restriction of hepatic competence by Fgf signaling.  Development 138, 1339-1348.

 

123.   Fish, J.E., Wythe, J.D., Xiao, T., Bruneau, B.G., Stainier D.Y.R., Srivastava, D. and Woo, S. (2011).  A Slit/miR-218/Robo regulatory loop is required during heart tube formation in zebrafish.  Development 138, 1409-1419.

 

124.   Delgado-Olguin, P., Brand-Arzamendi, K., Scott, I.A., Jungblut, B., Stainier D.Y.R., Bruneau, B.G. and

         Recillas-Targa, F. (2011).  CTCF promotes muscle differentiation by modulating the activity of myogenic

         regulatory factors. Journal of Biological Chemistry, in press.

 

125.   Hesselson, D., Anderson, R.M. and Stainier, D.Y.R. (20011). Suppression of Ptf1a activity induces acinar to endocrine conversion.  Current Biology, in press.

 

Review Articles and Book Chapters                           

 

1.      Stainier, D.Y.R. and Fishman, M.C. (1993).  Cardiac morphogenesis in the zebrafish, patterning the heart tube along the anteroposterior axis. In: Bernfield, M. (ed), Molecular Basis of Morphogenesis, 51 st Annual Symposium of the Society for Developmental Biology, John Wiley & Sons, New York, NY, pp 77-89.

 

2.      Stainier, D.Y.R. and Fishman, M.C. (1994).  The zebrafish as a model system to study cardiovascular development.  Trends in Cardiovascular Medicine 4: 207-212.

 

3.      Fishman, M.C. and Stainier, D.Y.R. (1994).  Cardiovascular development:  Prospects for a genetic approach.  Circulation Research 74: 757-763.

 

4.      Fishman, M.C., Stainier, D.Y.R.S., Breitbart, R. and Westerfield, M. (1997).  Zebrafish:  Genetic and embryological methods in a transparent vertebrate embryo.  In: Emerson, C.P. and Sweeney, H.L. (eds), Methods in Cell Biology, vol.52, Methods in Muscle Biology, Academic Press, San Diego, CA, pp 67-82.

 

5.      Alexander, J. and Stainier, D.Y.R. (1999).  Mutations affecting cardiac development in zebrafish.  In Heart Development.: (eds. Harvey, R. and Rosenthal, N.), pp. 91-110, Academic Press, San Diego, CA, pp 91-110.

 

6.      Parker, L.H., Zon, L. and Stainier, D.Y.R. (1999).  Blood and vascular gene expression.  In: Detrich, W., Zon, L. and Westerfield, M. (eds), Methods in Cell Biology, The Zebrafish, Academic Press, San Diego, CA, pp 313-336.

 

7.      Yelon, D. and Stainier, D.Y.R. (1999).  Patterning during organogenesis: genetic analysis of cardiac chamber formation.  Semin. Cell. Dev. Biol. 10: 93-98.

 

8.      Walsh, E. and Stainier, D.Y.R. (2000).  Cardiac development in vertebrates.  In Genetic models in Cardiorespiratory Biology (eds. Haddad, G.G. and Xu, T.; ex. ed. Lenfant, C.).  Marcel Dekker, NY, pp 203-238.

 

9.      Stainier, D.Y.R. (2001).  Zebrafish genetics and vertebrate heart formation.  Nature Reviews Genetics   2: 39-48.

 

10.     Warga, R.M. and Stainier, D.Y.R. (2002).  The guts of endoderm formation.  In Pattern Formation in Zebrafish (ed. Solnica-Krezel, L.).  Springer-Verlag, Berlin, pp 28-47.

 

11.     Stainier, D.Y.R. (2002).  (Traduit par Simone Gilgenkrantz).  Contribution du poisson zèbre à l’étude moléculaire du développement du coeur des vertébrés.  Médecine/Sciences 18:448-456.

 

12.     Jin, S-K, Jungblut, B. and Stainier, D.Y.R. (2002).  Angiogenesis during zebrafish development.  In Genetics of Angiogenesis, (ed. Jay Hoying).  Bios, Oxford pp. 101-118.

 

13.     Yelon, D. and Stainier, D.Y.R. (2002).  Pattern formation: swimming in retinoic acid.  Current Biology 12: R707-709.

 

14.     Scott, I. and Stainier, D.Y.R. (2002).  Fishing out a new heart.  Science 298: 2141-2142.

 

15.     Stainier, D.Y.R., Beis, D., Jungblut, B. and Bartman, T. (2002).  Endocardial cushion formation in zebrafish.  In The Cardiovascular System, proceedings of the 67th CSH Symposium on Quantitative Biology 67: 49-56.

 

16.     Stainier, D.Y.R. (2002). A glimpse into the molecular entrails of endoderm formation.  Genes & Development 16: 893-907.

 

17.     Sehnert, A. and Stainier, D.Y.R. (2002).  A window to the heart: can zebrafish mutants help us understand heart disease in humans?  Trends in Genetics 18: 491-494.

 

18.     Ober, E.A., Field, H.A. and Stainier, D.Y.R. (2003).  From endoderm formation to liver and pancreas development in zebrafish.  Mechanisms of Development 120: 5-18.

 

19.     Osborne, N. and Stainier, D.Y.R. (2003).  Lipid receptors in cardiovascular development.  Annual Review in Physiology 65: 23-43.

 

20.     Stainier, D.Y.R. and Pourquie, O. (2003).  Entrails, heart, brain, limbs, and lymphatics, a recipe for success?  Dev. Cell. 5: 193-196.

 

21.     Scott, I. and Stainier, D.Y.R. (2003).  Twisting the body into shape.  Nature 425: 461-463.

 

22.     Trinh, L.A. and Stainier, D.Y.R. (2004).  Cardiac Development.  In: Detrich, W., Zon, L. and Westerfield, M. (eds), Methods in Cell Biology, The Zebrafish, Academic Press, San Diego, CA, pp 455-473.

 

23.     Stainier, D.Y.R. (2005).  No organ left behind: Tales of gut development and evolution.  Science 307: 1902-1904.

 

24.     Beis, D. and Stainier, D.Y.R. (2005).  In vivo cell biology: following the zebrafish trend.  Trends in Cell Biology 16: 105-112.

 

25.     Stainier, D.Y.R. (2006).  No stem cell is an islet (yet).  NEJM 354: 521-523.

 

26.     Curado, S. and Stainier, D.Y.R. (2006). The HeArt of Regeneration.  Cell 127: 462-464.

 

27.     Schegel, A. and Stainier, D.Y.R. (2007).  Lessons from “lower” organisms: what worms, flies, and zebrafish can teach us about human energy metabolism.  PLoS Genetics 3: 2037-2048.

 

28.     Huisken, J. and Stainier, D.Y.R. (2009).  Selective plane illumination microscopy techniques in developmental biology.  Development 136, 1963-1975.

 

29.     Trinh, L.A. and Stainier, D.Y.R. (2009).  Cardiac Development.  In “Essential Zebrafish Methods: Cell and Developmental Biology, Academic Press, Philadelphia, PA, pp 479-499.

 

30.     Kawahara, A. and Stainier, D.Y.R. (2010). Noncanonical activity of Seryl-Transfer RNA Synthetase and vascular development. Trends in Cardiovascular Medicine 19, 179-182.

 

31.    Wilson, C.W. and Stainier, D.Y.R. (2010).  Vertebrate Hedgehog signaling: cilia rule.  BMC Biology 8,

         102-104.

 

32.     Curado, S. and Stainier D.Y.R. (2010).  deLiver’in regeneration: injury response and development. 

         Seminars in Liver Disease 30, 288-295.

 


5 SIGNIFICANT REFEREED PUBLICATIONS

 

Kupperman, E., An, S., Osborne, N., Waldron, S. and Stainier, D.Y.R. (2000).  A sphingosine 1-phosphate receptor regulates cell migration during vertebrate heart development.  Nature 406: 192-195.

 

Horne-Badovinac, S., Rebagliati, M. and Stainier, D.Y.R. (2003).  A cellular framework for gut looping morphogenesis in zebrafish.  Science 302: 662-665.

 

Ober, E.A., Verkade, H., Field, H.A. and Stainier, D.Y.R. (2006).  Mesodermal Wnt2b signaling positively regulates liver specification.  Nature 442: 688-691.

 

Vogeli, K.M., Jin, S.-W., Martin, G.R. and Stainier, D.Y.R. (2006).  A common progenitor for hematopoietic and endothelial lineages in the zebrafish gastrula.  Nature 443: 337-339.

 

Herbert, S.P., Huisken, J., Kim, T.N., Feldman, M.E., Houseman, B.T., Wang, R.A., Shokat, K.M. and Stainier, D.Y.R. (2009).  Arterial/Venous Segregation by Selective Cell Sprouting: An Alternative Mode of Blood Vessel Formation.  Science 326: 294-298.

 

RESEARCH STATEMENT

 

Our work is concerned with the formation, function and homeostasis of organs during vertebrate development.  We are interested in understanding the cellular and molecular events that underlie cellular differentiation, tissue morphogenesis and organ function during the formation of the cardiovascular system (the heart and the blood vessels) as well as the liver and pancreas.  Our initial approach consists of screening for mutations that affect these processes in zebrafish, a vertebrate model system that allows forward genetics as well as embryological studies.  This forward genetic approach leads to the isolation of genes critical for these processes, and together with complementary methods allows us to assemble underlying molecular pathways.  We also aim to understand how these genes control the behavior of the cells that form these complex three-dimensional structures, and the zebrafish allows one to study cell behavior in real time and in the context of the living embryo.  Ultimately, we would like to reach a systems level understanding of these processes.  And, as the work progresses, we also hope to contribute to the understanding of how defects in the processes we are studying lead to human congenital disease or malformations, or even to predisposition to disease.