CURRICULUM
VITAE
DIDIER
Y. R. STAINIER DOB: 10/31/1963
Professor citizenship: American/Belgian
Department of Biochemistry &
Biophysics
Director
of the UCSF Fellows Program, Co-Director of The Developmental and Stem Cell
Biology Program, Associate Director of The Liver Center; Member of the Tetrad
and BMS Graduate Programs, Cardiovascular Research Institute, Diabetes Center,
Institute for Regeneration Medicine, Cancer Center, and Human Genetics
Institute.
email: didier.stainier@ucsf.edu
www: http://www.ucsf.edu./dyrslab/
EDUCATION
|
Dates |
Institution and
Location |
Degrees conferred |
Major Subject |
|
1979-1981 |
United World Colleges,
|
International
Baccalaureate, Highest Honors |
Biology, Physics, Math |
|
1981-1982 |
Université de Liège, |
Certificate in Biology |
Biology |
|
1982-1984 |
|
B.A. Summa cum laude |
Biology |
|
1984-1990 |
|
Ph.D. Dr. Walter Gilbert |
Biochemistry and
Molecular Biology |
RESEARCH AND PROFESSIONAL EXPERIENCE
Principal
Positions Held
|
Dates |
Institution and
Location |
Position |
|
1990-1994 |
|
Postdoctoral Fellow Dr. Mark Fishman |
|
1995-present |
Department of
Biochemistry & Biophysics, |
Assistant, Associate
(2000), Full (2003) Professor |
HONORS AND AWARDS
|
1982-1984 |
Wien International Scholar, |
|
|
1983 |
Elihu A. Silver Prize for Undergraduate Research in Science, |
|
|
1984 |
Dr. Joseph Garrison Parker Prize in Biology, |
|
|
1984 |
Phi Beta Kappa, |
|
|
1991-1994 |
Helen Hay Whitney Foundation Postdoctoral Fellow |
|
|
1995 |
Louis N. Katz Basic Science Research Prize Finalist,
American Heart Association |
|
|
1995-2000 |
Packard Foundation Fellow in Science and Engineering |
|
|
1996-1998 |
Basil O'Connor Scholar, March of Dimes Foundation |
|
|
2000-2003 |
Established Investigator, American Heart Association |
|
|
2002 |
Mossman Award in Developmental Biology, American
Association of Anatomists |
|
|
2003-2004 |
Annual Byers Award in Basic Science, UCSF |
|
|
2003 |
Outstanding Faculty Mentorship Award, UCSF |
|
|
2003-2006 |
NIH DEV1, study section Chair |
|
|
2008 |
J.W. Jenkinson
Memorial Lectureship, |
|
|
2008 |
Fellow of the
American Association for the Advancement of Science |
|
KEYWORDS/RESEARCH INTERESTS
Vertebrate
organ formation/cardiovascular development/endoderm, liver, pancreas and gut
development/ regeneration/stem cell differentiation/lipid
transport/gluconeogenesis/metabolism
PROFESSIONAL ACTIVITIES
Editorial boards
1997-2007
Editorial Board Member, Developmental Biology
2001-2006 Associate
Editor, Developmental Dynamics
2002-2003 Faculty of 1000, Faculty Member
2004-present Editorial Board Member, Development
2004-present Editorial Board Member, Zebrafish
2004-present Editorial Board Member then Section
Editor, BMC Developmental Biology
2006-present Managing Editor, Mechanisms of Development
Manuscript review
Nature, Science, Cell, Genes and Development,
Developmental Cell, Nature Genetics, Nature Cell Biology, Nature Medicine, Nature Methods, Nature Reviews
Genetics, Nature Chemical Biology, PLoS Biology, PLoS Genetics, PNAS, Current
Biology, EMBO Journal, TIGS, TCB, Development, Developmental Biology,
Developmental Dynamics, Mechanisms of Development, MBC, J. of Experimental
Biology, FASEB journal, Zebrafish, Circulation Research, Blood, JCI, Genome
Research, Hepatology, Diabetes, Pancreas, Lipids,...
Grant review
Ad Hoc reviewer for NIH, NSF, HHMI, as well as various scientific organizations in the EU, Canada, the United Kingdom, Ireland, Germany, the Netherlands, Belgium, France, Israel, Singapore, Taiwan and Hong Kong.
1996-2000
American Heart
Association (Western Affiliates) study section member
1999 National Science
Foundation, Developmental Mechanisms study section member
2000 American Cancer Society
(National), DDC Peer Review committee member
2000-2002 American Heart Association
(National Committee) study section member
2001 NIH CDF5 study section ad hoc member (plus ad hoc on special study sections, PPGs)
2001 NASA, Developmental
Biology study section member
2002-present NIH ECS, VCMB, MET, SBDD, CADO, SEP
and GCMB study sections ad hoc
2003 European Commission FP6
Evaluation member
2003-2006
NIH DEV1, study
section Chair
2008 Special
Emphasis Panel: Tools for Zebrafish Research, study section Chair
2009-present Juvenile Diabetes Research Foundation
study section member
2009 European Commission FP7
Evaluation member
2010-2012 NIH College of Center for Scientific Review member
2011 Deutsche
Forschungsgemeinschaft Excellence Initiative reviewer,
Service to Professional Organizations
1998-2000 Member, NIH Advisory Committee on
Zebrafish Genetics and Genomics
2001-2004
Society of Dev.
Biology Board of Directors, elected West Coast Representative
2002 Co-organizer,
5th International Meeting on Zebrafish Development and Genetics,
2003 External Scientific Advisory
Committee, Molecular Cardiovascular Medicine Group,
2003, 2004 Member,
then Chair, Mossman Award Selection Committee, American Association of
Anatomists
2004-2009 Member, External Advisory Committee,
2004-2008 Selection Committee, Strategic
Conference of Zebrafish Investigators
2005-2008 Member, Zebrafish Investigators
Steering Committee
2006 Keystone Symposia, Development
Study Group
2007-present Regeneration Project,
2008 External Scientific Advisory
Committee, IMCB,
2009-present Keystone Symposia's
Scientific Advisory Board, ad hoc then full member
2010 Scientific advisory Committee
for IVBM
2010 (International Vascular Biology Meeting)
2010-2013 External Advisor, BOLD (European
Network on ‘Biology of Liver and Pancreatic Development and Disease’)
2010 Scientific Academic Advisory Committee, Weizmann
Institute of Science
Other
2004 Scientific Advisory Committee
for a special publication by Nature
entitled: Milestones in
Development.
2008 Co-Organizer, Japanese-Bay Area
Vertebrate Organogenesis Conference
2011 Speaker and Participant, NICHD
Vision Workshop on Development
2011 Co-Organizer, UNIA
Workshop on ‘Liver and Pancreas Development and Disease’, Baeza,
INVITED PRESENTATIONS (since 2006)
Named lectures and plenary talks are
indicated in bold.
2006
INTERNATIONAL:
British Society of Developmental Biology Annual meeting,
3rd Canadian Developmental Biology Conference, Mont-Tremblant,
Max Delbrück Centrum Conference on Epithelial organization and
Organ development,
3rd
EMBO Conference on Regeneration and Tissue Repair
4th International Kloster Seeon Meeting on
"Angiogenesis",
KIX Symposium on “Genomic
medical science and heart disease”
Hospital
for Sick Children,
NATIONAL:
Burnham
Institute,
Keystone
Symp. ‘Molecular Mechanisms of Cardiac Disease & Regeneration’, speaker,
plenary session chair
NAVBO,
Developmental Vascular Biology Workshop,
UCLA
Institute for Pure and Applied Mathematics,
Angiogenesis, NeoVascularization and
Morphogenesis workshop
UCSF
liver center retreat, Mill valley, CA
FASEB
conference on mechanisms of liver growth, development and disease,
Developmental
Dynamics symposium,
UCSF,
Minimed series
University
of
Gordon
Research Conference on endothelial cell phenotypes in health & disease,
Vasculata 2006, UCLA, instructor
University
of
UCSF
BMS seminar series,
University
of
2007
INTERNATIONAL:
Biozentrum,
First Pan American Congress in Developmental Biology,
ComBio, Sydney, Australia,
Plenary speaker
ComBio,
‘Drilling into life´s depth – innovative methods in molecular
biology’, student organized symposium at the
Foundation for Biomedical Research of the Academy of
Zebrafish Development and Disease Course, Hubrecht
Laboratory,
NATIONAL:
Systems
Medicine Workshop, NHLBI,
New
York University Medical School, Skirball Institute.
UCSF/Karolinska Institute Stem Cell Symposium
UCSD Cardiovascular Science Conference
West Coast SDB meeting,
Regenerative Medicine Seminar,
Keystone
Symposium on Tissue engineering and developmental biology, Snowbird, UT
University
of
Plenary speaker (declined)
American
Diabetes Association,
4th Annual Symposium of the AHA Council on Basic Cardiovascular
Sciences – Cardiovascular Repair and
Regeneration:
Structural and Molecular Approaches in the Cellular Era, Keystone, CO
FASEB
conference on gastrointestinal tract XII: The molecular and integrative basis
for GI
development, homeostasis & disease,
Zebrafish
investigators' workshop,
UNC,
2008
INTERNATIONAL:
“From Developmental Biology to tissue regeneration” international
workshop,
International Symposium on ‘Stem cells in Development,
Regeneration and Disease,
Temasek Life Sciences Laboratory,
Centro Nacional de Investigaciones
Distinguished
Scientist Lecture Series, Max Planck Institute for Developmental Biology,
invited by the graduate students
J.W. Jenkinson Memorial Lectureship,
41st
Japanese Society of Developmental Biology, International Society of
Developmental Biology joint
meeting,
XX International Congress of Genetics 2008,
Annual Conference, EU FP6 Integrated Project ‘HeartRepair’,
Journée Claude Bernard de la Société de Biologie,
4th meeting of the Latin American Society of Developmental Biology,
NATIONAL:
NAVBO,
Developmental Vascular Biology Workshop, Asilomar, CA
FASEB
conference on mechanisms of liver growth, development and disease, Snowmass, CO
Iowa State University, Ames, Iowa
Teratology Society 48th Annual meeting, Monterey,
CA
2008 Beta cell Biology Consortium Retreat
Plenary Speaker, Washington DC
Case
Western Reserve University, Cleveland, OH (invited by the graduate students)
8th International Meeting on Zebrafish Development and Genetics,
Madison, WI
Developmental
Biology Symposium at the University of Minnesota, Minneapolis, MN
Woods
Hole Embryology course, Woods Hole, MA
Tufts
University, Boston, MA
UCSF,
Cardiology Grand Rounds
Gordon
Research Conference on Molecular Cell Biology, New London, NH
Keystone
Symposium on Pathological and Physiological
Regulation of Cardiac Hypertrophy, (declined)
UC
Davis, Davis, CA
University
of Michigan Medical School, Ann Arbor, MI
SF-Japan Joint meeting on vertebrate organogenesis, San
Francisco, CA
Dana-Farber
Cancer Institute, Boston, MA
ASCB Annual Meeting, Symposium speaker,
San Francisco, CA
2009
INTERNATIONAL:
Belgian
Society for Cell and Developmental Biology, Leuven, Belgium
Keystone
Symposium on Stem Cell Niche interactions, Whistler,
Canada
66th
KSBMB Annual Meeting, Seoul, South Korea
Korea
University, Seoul, South Korea
Kyungpook National
University, Daegu city, South Korea
Chungnam National
University, Daejeon city, South Korea
KAIST, Daejeon city,
South Korea
Center for Regenerative Therapies Dresden, Summer Conference,
Keynote Speaker, Germany
Advances in Heart Development:
from molecules to cures, Fondation des Treilles, France
Workshop,
Mechanisms of Organ Regeneration in Model Systems, Baeza, Spain
Center for Molecular Biosciences meeting,
Plenary speaker, Innsbruck, Austria
NATIONAL:
University
of Miami, Cell Biology and Anatomy, Miami, FL
Tulane
University, New Orleans, LA
Zebrafish
investigators' workshop, Asilomar, CA
Gordon
Research Conference on Vascular Biology, Ventura, CA, (declined)
Northwest
Society of Developmental Biology, Plenary talk, Friday Harbor labs, (declined)
Duke
University, DSCB colloquium, Durham, NC
Insittute
of Regenerative Medicine retreat, Asilomar, CA
Digestive Disease Week, State-of-the-Art
Lecture, Chicago, IL
Riley
Heart Center Symposium on Cardiac Development, Indianapolis, IN
Keystone
Symposium on Cardiac Disease: Development, Regeneration, and Repair, (declined)
American
Liver Foundation meeting, Boston, MA
Vanderbilt
University, Nashville, TN
Rachford Lecture, Cincinnati Children’s
Hospital Medical Center, Cincinnati, OH
National
Human Genome Research Institute, NIH, Bethesda, MD
UC Berkeley, Department of Nutritional Sciences and Toxicology, Berkeley,
CA
2010
INTERNATIONAL:
Biology
of Liver and Pancreas Development and Disease (BOLD), Birmingham, UK
8th
Annual CDB symposium, Frontiers in Organogenesis, RIKEN CDB, Kobe, Japan
Regulatory
Peptides 2010 Meeting, Belfast, Northern Ireland
5th
EMBO Conference on Regeneration and Tissue Repair Lisbon,
Portugal
Heraeus meeting on
Self-Organization in Cell Assemblies and Tissues, Bad Honnef, Germany
(declined)
New Frontiers in
Transcriptional Regulation, BOLD Network meeting, Cambridge, UK
Frontiers in
Developmental Biology, Weizmann Institute, Israel
16th
International Conference of the International Society of Differentiation, Nara,
Japan
Max Planck Institutes
colloquium on ‘Frontiers in Cardiopulmonary Research’, Munich, Germany
Annual Meeting of
Molecular Biology, BMB2010, Kobe, Japan
University of Tokyo,
Japan (declined)
Institute of Genetics
and Molecular and Cellular Biology, Strasbourg, France
NATIONAL:
NAVBO,
Developmental Vascular Biology Workshop, Asilomar, CA
Keystone
Symposium on Angiogenesis in Health and Disease,
Keystone, CO
Juvenile Diabetes Research Foundation Niche Symposium, New York,
NY
Inaugural symposium on Diabetes, UCSD Pediatric Diabetes Research
Center
National Heart, Lung and Blood Institute, NIH, Bethesda, MD
Inaugural Cold Spring Harbor symposium on Vertebrate
Organogenesis, CSH, NY
Novartis Institute for Biomedical Research, Cambridge, MA
3rd Annual Penn Cardiovascular Institute Symposium,
University of Pennsylvania, Philadelphia, PA
15th International Symposium on the Cells
of Hepatic Sinusoid, State-of-the-Art lecture, Pasadena, CA
University
of Texas at Austin, Austin, TX
Stanford
University
Frontiers in Biological Research Seminar Series, Palo Alto, CA
International Vascular
Biology Meeting 2010, UCLA, Los Angeles, CA
Texas
A&M Molecular &Cellular Medicine, College Station, TX
UCLA
Interdepartmental Genetics Seminar Series, Los Angeles, CA
FASEB
conference on mechanisms of liver growth, development and disease, Snowmass, CO
Heart
Failure Society of America Meeting, San Diego, CA
3rd Warshaw
Developmental Biology Symposium, Yale, New Haven, CT
Maternal,
Fetal and Neonatal Health Research Symposium, UCSF, San
Francisco, CA
American Society of
Hematology, Orlando, FL
2011
INTERNATIONAL:
EMBO
meeting on advances in Stem Cell research, Paris, France
New
Frontiers in Screening Technology, BOLD Network meeting, Karlsruhe, Germany
European
Cystic Fibrosis Society, Tirrenia-Pisa, Italy (declined)
8th International
Duodecim Symposium on Vascular Biology, Vanajanlinna, Hämeenlinna, Finland
International Society
for Stem Cell Research 9th Annual Meeting, Toronto, Canada
2011 German Genetics Society Annual Meeting Plenary talk,
Wuerzburg, Germany
UNIA
Workshop on ‘Liver and Pancreas Development and Disease’, Baeza, Spain
NATIONAL:
Zebrafish
investigators' workshop, Asilomar, CA
Keynote speaker, Gordon Research Conference
on Vascular Cell Biology, Ventura, CA
Northwest Regional Society for
Developmental Biology, Arthur Whitely Lecture, Friday Harbor, WA
Distinguished
Lecture Series in Cardiovascular Biology, UT Southwestern Medical Center,
Dallas, TX
National
Institute of Child Health and Human Development Workshop on Development,
Bethesda, MD
Diabetes
Center, UCSF, San Francisco, CA
Mechanism of Organ Repair & Regeneration, Washington, DC
(declined)
Beta Cell Biology Consortium Meeting, Washington, DC
Harvard Stem Cell Institute, Boston, MA
NIH Wednesday Afternoon Lecture Series,
NIH Office of the Director, Bethesda, MD
Biology of Signaling in
the Cardiovascular System Workshop, Hyannis, MA
UCSF COMMITTEES AND OTHER SERVICE (past 4
years)
2007-2008
Member
of the Biochemistry/Biophysics Departmental Cabinet
Tetrad
Graduate Curriculum Committee
PIBS
executive Committee
BMS
executive Committee
Steering
Committee, Program in Craniofacial and Mesenchymal
Biology
UCSF
Fellows Steering Committee
Department
of Biochemistry/Biophysics Animal Welfare Committee
UCSF
Fellows Search Committee
GESCR
Committee
Executive Committee and Annual Retreat Organizer, Developmental
Biology Program
Associate Director, Liver Center
2008-2009
Co-Director and Annual Retreat Organizer, Developmental Biology
Program
Associate Director, Liver Center
Member
of the Biochemistry/Biophysics Departmental Cabinet
Tetrad
Graduate Curriculum Committee
PIBS
executive Committee
BMS
executive Committee
Steering
Committee, Program in Craniofacial and Mesenchymal
Biology
UCSF
Fellows Steering Committee
Department
of Biochemistry/Biophysics Animal Welfare Committee
UCSF
Fellows Search Committee
GESCR
Committee
Gladstone
Cardiovascular Search Committee
CVRI Search Committee
2009-2010
Co-Director and Annual Retreat Organizer, Developmental Biology
Program
Associate Director, Liver Center
Co-Director, UCSF Fellows Program
Member
of the Biochemistry/Biophysics Departmental Cabinet
Tetrad
Graduate Curriculum Committee
PIBS
executive Committee
BMS
executive Committee
Steering
Committee, Program in Craniofacial and Mesenchymal
Biology
Department
of Biochemistry/Biophysics Animal Welfare Committee
GESCR
Committee
CVRI Search Committee
2010-2011
Director, UCSF Fellows Program
Co-Director, Developmental and Stem Cell Biology Program
Associate Director, Liver Center
Member
of the Biochemistry/Biophysics Departmental Cabinet
Tetrad
Graduate Curriculum Committee
PIBS
executive Committee
BMS
executive Committee
Department
of Biochemistry/Biophysics Animal Welfare Committee
Cell
Culture Facility Users Advisory Committee
CVRI Search Committee
TEACHING
Graduate Students
currently in the lab
Anna Read (Tetrad, NSF fellowship, entered grad school 2008; joint student with Orion Weiner)
David Staudt (BMS, MSTP, entered grad school 2009)
Postdoctoral fellows
currently in the lab
|
2006-present |
Dan Hesselson, Ph.D. |
University of
Wisconsin, Madison, WI Hillblom and JDRF
Fellowships |
|
2007-present |
Jiandong Liu, Ph.D. |
University of
Michigan, Ann Arbor, MI AHA postdoctoral
Fellowship and Training Grant Fellowship |
|
2007-present |
Chunyue Yin, Ph.D. |
Vanderbilt University,
Nashville, TN JDRF postdoctoral
Fellowship |
|
2007-present |
Yoshiko Kametani,
Ph.D. |
Kyoto University,
Japan JSPS and Human
Frontier Science Program Fellowship |
|
2007-present |
Shane Herbert, Ph.D. |
University of Leeds,
England Sir Henry Wellcome
Fellowship, UK |
|
2007-present |
Stephanie Woo, Ph.D. |
University of
Wisconsin, Madison, WI CVRI training grant |
|
2008-present |
Olov Andersson, Ph.D. |
Karolinska Institute,
Sweden Swedish Research Council
and EMBO fellowships |
|
2008-present |
Philipp Gut, M.D. |
University of
Heidelberg DFG postdoctoral
Fellowship |
|
2009-present |
Marion Delous, Ph.D. |
University Paris V, France French Foundation Medical Fellowship |
|
2009-present |
Michael Housley, Ph.D. |
Johns Hopkins
University, Baltimore, MD CIRM training grant |
|
2009-present |
Nikolay Ninov, Ph.D. |
University of
Barcelona, Spain Canadian Diabetes
Foundation Fellowship |
|
2009-present |
Benoit
Vanhollebeke, Ph.D. |
University of
Brussels, Belgium EMBO and Human Frontier
Science Program Fellowships |
|
2009-present |
Sven Reischauer,
Ph.D. |
MPI, Tuebingen DFG and AHA
Postdoctoral Fellowships |
|
2010-present |
Kim Evason,
M.D., Ph.D. |
Washington University,
St. Louis Damon Runyon
Fellowship |
|
2010-present |
Suphansa
Sawamiphak, Ph.D. |
Goethe University,
Frankfurt, Germany |
|
2010-present |
Oliver Stone,
Ph.D. |
University of Bristol,
England |
|
2010-present |
Aly Villasenor,
Ph.D. |
UT Southwestern
Medical Center, Dallas, TX |
Graduate Students who
have left the lab and their current position
|
John Alexander, MD,PhD |
Tetrad, AHA Fellowship |
Molecular Medicine Fellow, UC San
Francisco |
|
Jeremy Reiter, MD, PhD |
Tetrad, ARCS
Fellowship |
Assistant Professor, UC San
Francisco |
|
Emily Walsh, PhD |
Tetrad, HHMI Predoctoral
Fellowship |
Program Manager, Alnylam Pharmaceuticals |
|
Sally Horne, PhD |
Tetrad, AHA Predoctoral
Fellowship |
Assistant Professor, University of
Chicago School of Medicine |
|
Holly Field, PhD |
Tetrad |
Medical Writer, Cambridge, MA |
|
Le Trinh, PhD |
BMS, NSF Predoctoral
Fellowship AHA Predoctoral Fellowship |
Postdoctoral Fellow with Scott
Fraser, Caltech |
|
Nick Osborne, PhD |
BMS, NSF Predoctoral
Fellowship |
Postdoctoral Fellow with Terry
Magnuson, University of North Carolina |
|
Kevin Vogeli, PhD |
Tetrad, NSF Predoctoral
Fellowship |
Medical Student, University of
Southern California |
|
Chantilly Munson, PhD |
Tetrad, NSF Predoctoral
Fellowship |
Assistant Professor, City College
of San Francisco |
|
Won-Suk Chung, PhD |
BMS, Genentech
Fellowship CIRM Fellowship |
Damon Runyon Postdoctoral Fellow
with Ben Barres, Stanford University |
|
Isla Cheung, PhD |
Tetrad, ARCS
Fellowship |
Postdoctoral Fellow at UCSF |
Postdoctoral Fellows
who have left the lab and their current position (most
recent listed last)
|
Leon Parker, PhD |
NIH NRSA Fellowship |
Staff Scientist, Genentech, Inc.,
So San Francisco, CA |
|
Chi-Yip Ho, PhD |
AHA Fellowship |
Director, Microarray Facility, Lunenfeld Res. Inst.,
Toronto, Canada |
|
Wayne Liao, PhD |
AHA Fellowship |
Program Manager, TLC pharmaceuticals, Mountain View, CA |
|
Erik Kupperman, PhD |
NSF Fellowship UC President’s Fellowship |
Senior scientist, Curagen, Cambridge |
|
Birgitta Olofsson, PhD |
|
Assistant Professor, Cambridge, England |
|
Deborah Yelon, PhD |
LSRF Fellowship Burroughs Wellcome
Fellowship |
Professor, UC San Diego |
|
Amy Sehnert, MD, PhD |
PSDP Fellowship NIH K08 Grant AHA and BGIA Fellowships |
Senior Director, Artemis Health, San Carlos,
CA |
|
Yutaka Kikuchi, PhD |
HFSP Fellowship |
Professor, Hiroshima University, Japan |
|
Tom Bartman, MD, PhD |
HHMI Postdoctoral
Research Fellowship for Physicians |
Assistant Professor, Cincinnati Children's
Hospital Medical Center |
|
Julie Frantsve, PhD |
CVRI Training Grant
Fellowship |
Assistant Director,
ADA Council on Scientific Affairs |
|
Heather Verkade, PhD |
HFSP Fellowship |
Assistant Professor, Monash University,
Melbourne, Australia |
|
Federica Bertocchini,
PhD |
|
Postdoctoral Fellow, UCL, London, UK |
|
Dimitris Beis, PhD |
HFSP Fellowship |
Assistant Professor, Academy of Athens, Greece |
|
Tracy Mitchell, PhD |
CVRI Training Grant
Fellowship |
Senior Scientist, Adnexus, Boston, MA |
|
Elke Ober, PhD |
AHA Fellowship |
Assistant Professor, Mill Hill, London, UK |
|
Suk-Won Jin, PhD |
AHA Fellowship |
Assistant Professor, Yale University, New Haven, CT |
|
Ian Scott, PhD |
MRC of Canada
Fellowship |
Assistant Professor, Hospital for Sick
Children, Toronto, Canada |
|
Leonard D’Amico, PhD |
NIH NRSA Fellowship |
Postdoctoral Fellow, Seattle, WA |
|
Tatiana Hochgreb, PhD |
Pew Foundation
Fellowship |
Postdoctoral Fellow, Caltech, Pasadena, CA |
|
Benno Jungblut, PhD |
MPI Fellowship AHA Fellowship |
Junior Group Leader, MPI Bad Nauheim, Germany |
|
Pia Aanstad, PhD |
|
Assistant Professor, University of Innsbruck,
Austria |
|
Massimo Santoro, PhD |
EMBO Fellowshp HFSP Fellowship |
Assistant Professor, University of Turino,
Italy |
|
Wiebke Herzog, PhD |
DFG Fellowship AHA Fellowship |
Junior Group Leader, MPI Muenster, Germany |
|
Paul Scherz, PhD |
Helen Hay Whitney
Fellowship |
Student, University of Notre Dame, IN |
|
Michel Bagnat, PhD |
EMBO Fellowship |
Assistant Professor, Duke University Medical
Center, Durham, NC |
|
Duc Dong, PhD |
JDRF Fellowship Hillblom Fellowship |
Assistant Professor, Burnham Institute, San
Diego, CA |
|
Neil Chi, MD, PhD |
AHA Fellow to Faculty
Award NIH K08 Grant |
Assistant Professor, UC San Diego, CA |
|
Lingfei Luo, PhD |
JDRF Senior
Postdoctoral Fellowship |
Assistant Professor, Southwest University,
China |
|
Silvia Curado, PhD |
CVRI Fellowship |
Program Manager, New York University, NY |
|
Jan Huisken, PhD |
HFSP Fellowship |
Junior Group Leader, MPI Dresden, Germany |
|
Takuya Sakaguchi, PhD |
APS Fellowship NIH K99 Grant |
Assistant Professor, Cleveland Clinic,
Cleveland, OH |
|
Ryan Anderson, PhD |
JDRF Fellowships |
Assistant Professor, Indiana University School
of Medicine, Indianapolis, IN |
|
Chong Shin, PhD |
NIH NRSA Fellowship NIH K01 Grant |
Assistant Professor, Georgia Institute of Technology, Atlanta, GA |
|
Donghun Shin, PhD |
JDRF Fellowship |
Assistant Professor, University of Pittsburgh Medical School, Pittsburgh, PA |
|
Amnon Schlegel, MD,
PhD |
NIH K08 Grant |
Assistant Professor, University of Utah Medical School, Salt Lake City, UT |
Special students and
other lab visitors (partial list since 2005)
|
2005 |
Jessica Ahlsiö,
visiting Ph.D. student from Lund University, Sweden |
|
2005 |
Joaquin Grego Bessa,
visiting Ph.D. student from Madrid, Spain |
|
2005-2006 |
Rima Arnaout, Sarnoff
fellow from Harvard Medical School |
|
2005-2006 |
Colin Lorentzen, Diana
Kuo, UCB undergraduates |
|
2006 |
Guillaume Gibon,
visiting master’s student from Paris, France |
|
2006 |
Pankaj Sahai, SRTP
student from the University of Puerto Rico |
|
2006, 2007 |
Linda Setiawan, visiting
Diploma student from Freie Universitaet Berlin |
|
2006 |
Frederic Marteau,
Ph.D., sabbatical scientist from the Universite libre de Bruxelles |
|
2007 |
Emmanuelle Szenker,
visiting master’s student from Paris, France |
|
2007 |
Gabriella Pesce,
visiting postdoctoral fellow from University of
Piemonte, Italy |
|
2007 |
Nik Tomanovic,
visiting student from Cambridge University, UK |
|
2008 |
Marine Beinat,
visiting master’s student from Paris, France |
|
2009 |
Julie Prudhomme,
visiting master’s student from Paris, France |
|
2010 |
Laetitia Lemeray,
visiting master’s student from Paris, France |
|
2010 |
Philbert Lee, SFSU
master’s student, CIRM Bridges grantee |
|
2010 |
Jennifer Hampton,
Humboldt State University master’s student, CIRM Bridges grantee |
|
2010 |
Naoki Tsuji, Ph.D.,
visiting scientist from Daiichi-Sankyo Co., Tokyo, Japan |
Faculty Mentoring:
Darren Schneider (KO8 mentor), Miguel Ramalho-Santos, Pao-Tien Chuang, Jeremy
Reiter, David Bilder (UCB), Maria Barna, Ross Metzger. I have read and critiqued grant applications
and manuscripts. I have also offered
advice and feedback re various scientific and academic growth matters.
Teaching Award:
|
2003 |
Outstanding Faculty Mentorship Award, UCSF |
PEER REVIEWED RESEARCH ARTICLES
*indicates
12 most significant publications
1. Stainier,
D.Y.R. and Gilbert, W. (1989). The
monoclonal antibody B30 recognizes a specific neuronal cell surface antigen in
the developing mesencephalic trigeminal nucleus of the mouse. J.
Neurosci. 9: 2468-2485.
2. Stainier,
D.Y.R. and Gilbert, W. (1990). Pioneer
neurons in the mouse trigeminal sensory system.
Proc. Natl. Acad. Sci. USA 87: 923-927.
3. Stainier,
D.Y.R. and Gilbert, W. (1991). Neuronal
differentiation and maturation in the mouse trigeminal sensory system, in vivo
and in vitro. J. Comp. Neurol. 311: 300-312.
4. Stainier,
D.Y.R., Bilder, D.H. and Gilbert, W (1991). The B30 ganglioside is a cell
surface marker for neural crest-derived neurons in the developing mouse. Developmental
Biology 144: 177-188.
5. Stainier,
D.Y.R., Bilder, D.H. and Gilbert, W (1991).
Spatial domains in the developing forebrain: developmental regulation of
a restricted cell surface protein. Developmental Biology 147: 22-31.
6. Stainier,
D.Y.R. and Fishman, M.C. (1992).
Patterning the zebrafish heart tube: acquisition of anteroposterior
polarity. Developmental Biology 153:
91-101.
7. Stainier,
D.Y.R., Lee, R.K. and Fishman, M.C. (1993).
Cardiovascular development in the zebrafish: I. Myocardial fate map and
heart tube formation. Development 119: 31-40.
8. Abdelilah, S.,
Solnica-Krezel, L., Stainier, D.Y.R. and Driever, W. (1994). Implications for dorsoventral axis
determination from the zebrafish mutation janus. Nature
370: 468-471.
9. Lee, R.K.K.,
Stainier, D.Y.R., Weinstein, B.W. and Fishman, M.C. (1994). Cardiovascular development in the
zebrafish: II. Endocardial progenitors are sequestered
within the heart field. Development 120: 3361-3366.
10. Stainier,
D.Y.R., Weinstein, B.M.W., Detrich H.W., Zon, L.I. and Fishman, M.C. (1995). cloche, an early acting zebrafish gene,
is required by both the endothelial and hematopoietic lineages. Development
121, 3141-3150.
11. Driever, W., Solnica-Krezel, L., Schier,
A.F., Neuhauss, S.C.F., Malicki, J., Stemple, D.L., Stainier, D.Y.R.,
Zwartkruis, F., Abdelilah, S., Rangini, Z., Belak, J. and Boggs, C.
(1996). A genetic screen for mutations
affecting embryogenesis in zebrafish. Development 123:37-46.
12. Solnica-Krezel,
L., Stemple, D. L., Mountcastle-Shah, E., Rangini, Z., Neuhauss, S. C. F.,
Malicki, J., Schier, A. F., Stainier, D. Y. R., Zwartkruis, F., Abdelilah, S.
and Driever, W. (1996). Mutations
affecting cell fates and cellular rearrangements during gastrulation in
zebrafish. Development 123: 67-80.
13. Stemple, D. L.,
Solnica-Krezel, L., Zwartkruis, F., Neuhauss, S. C. F., Schier, A. F., Malicki,
J., Stainier, D. Y. R., Abdelilah, S., Rangini, Z., Mountcastle-Shah, E. and
Driever, W. (1996). Mutations affecting
development of the notochord in zebrafish.
Development 123: 117-128S
14. Schier, A. F.,
Neuhauss, S. C. F., Harvey, M., Malicki, J., Solnica-Krezel, L., Stainier, D.
Y. R., Zwartkruis, F., Abdelilah, S., Stemple, D. L., Rangini, Z., Yang, H. and
Driever, W. (1996). Mutations affecting
the development of the embryonic zebrafish brain. Development
123: 165-178.
15. Abdelilah, S.,
Mountcastle-Shah, E., Harvey, M., Solnica-Krezel, L., Schier, A. F., Stemple,
D. L., Malicki, J., Neuhauss, S. C. F., Zwartkruis, F., Stainier, D. Y. R.,
Rangini, Z. and Driever, W. (1996).
Mutations affecting neural survival in the zebrafish, Danio rerio. Development
123:217-227.
16. Malicki, J., Neuhauss,
S. C. F., Schier, A. F., Solnica-Krezel, L., Stemple, D. L., Stainier, D. Y.
R., Abdelilah, S., Zwartkruis, F., Rangini, Z. and Driever, W. (1996). Mutations affecting development of the
zebrafish retina. Development 123: 263-273.
17. Malicki, J.,
Schier, A. F., Solnica-Krezel, L., Stemple, D. L., Neuhauss, S. C. F.,
Stainier, D. Y. R., Abdelilah, S., Rangini, Z., Zwartkruis, F. and Driever, W.
(1996). Mutations affecting development
of the zebrafish ear. Development 123: 275-283.
18. Stainier, D. Y.
R., Fouquet, B., Chen, J.-N.,
19. Weinstein, B.
M., Schier, A. F., Abdelilah, S., Malicki, J., Solnica-Krezel, L., Stemple, D.
L., Stainier, D. Y. R., Zwartkruis, F., Driever, W. and Fishman, M. C.
(1996). Hematopoietic mutations in the
zebrafish. Development 123:
303-309.
20. Neuhauss, S. C.
F., Solnica-Krezel, L., Schier, A. F., Zwartkruis, F., Stemple, D. L., Malicki,
J., Abdelilah, S., Stainier, D. Y. R. and Driever, W. (1996). Mutations affecting craniofacial development
in zebrafish. Development 123:
357-367.
21. Ticho, B.S.,
Stainier, D.Y.R., Fishman, M.C. and Breitbart, R.E. (1996). Three zebrafish MEF2 genes delineate somitic
and cardiac muscle development in wild-type and mutant embryos. Mechanisms
of Development 59:205-218.
22. Liao, W.,
Bisgrove, B.W., Sawyer, H., Hug, B., Bell, B., Peters, K., Grunwald, D.J. and
Stainier, D.Y.R. (1997). The zebrafish
gene cloche acts upstream of a flk-1
homologue to regulate endothelial cell differentiation. Development
124: 381-389.
23. Alexander, J.,
Stainier, D.Y.R. and Yelon, D. (1998).
Screening mosaic F1 females for mutations affecting zebrafish heart
induction and patterning. Developmental Genetics 22: 288-299. D.Y.R.S. senior author.
24. Lyons, M.S.,
Bell, B., Stainier, D.Y.R. and Peters, K. (1998). Isolation of the zebrafish homologues for the
tie-1 and tie-2 endothelium specific receptor tyrosine kinases. Developmental
Dynamics 212: 133-140.
25. Haun, C.,
Alexander, J., Stainier, D.Y.R. and Okkema, P.G. (1998). Rescue of C. elegans pharyngeal development
by a vertebrate heart specification gene.
Proc. Natl. Acad. Sci. USA 95: 5072-5075.
26. Reifers, F., Bohli, H., Walsh, E.C.,
Stainier, D.Y.R. and Brand, M. (1998).
Fgf8 is mutated in zebrafish acerebellar
mutants and is required for maintenance of midbrain-hindbrain boundary
development and somitogenesis. Development 125: 2381-2395.
27. Karlovich, C.A., John, R., Ramirez, L.,
Stainier, D.Y.R. and Myers, R.M. (1998).
Characterization of the
28. Parker, L.H. and Stainier, D.Y.R.
(1999). Cell-autonomous and
non-autonomous requirements for the zebrafish gene cloche in hematopoiesis. Development 126: 2643-2651.
29. Yelon, D., Horne, S.A. and Stainier, D.Y.R.
(1999). Restricted expression of cardiac
myosin genes reveals regulated aspects of heart tube assembly in
zebrafish. Developmental Biology 214:
23-37.
30. Alexander, J., Rothenberg, M., Henry, G.L.
and Stainier, D.Y.R. (1999). casanova plays an early and essential
role in endoderm formation in zebrafish.
Developmental Biology 215: 343-357.
31. Ho, C.Y., Houart, C., Wilson, S.W., and
Stainier, D.Y.R. (1999). A role for the
extraembryonic yolk syncytial layer in patterning the zebrafish embryo
suggested by properties of the Hex gene. Current
Biology 9: 1131-1134.
*32. Alexander, J. and Stainier, D.Y.R.
(1999). A molecular pathway leading to
endoderm formation in zebrafish. Current Biology 9: 1147-1157. See
Commentary in Current Biology 9: R812-815.
33. Reiter, J., Alexander, J., Rodaway, A.,
Yelon, D. Patient, R., Holder, N. and Stainier, D.Y.R. (1999). Gata5 is required for the development of the heart
and endoderm in zebrafish. Genes & Development 13: 2983-2995.
34. Reifers, F., Walsh, E., Leger, S.,
Stainier, D.Y.R. and Brand, M. (2000).
Induction and differentiation of the zebrafish heart requires Fgf8. Development
127: 225-235.
35.
Griffin,
K.J.P., Stoller, J., Gibson, M., Chen, S., Yelon, D., Stainier, D.Y.R. and
Kimelman, D. (2000). A conserved role
for H15-related T-box transcription factors in zebrafish and Drosophila heart formation. Developmental
Biology 218: 235-247.
36. Kikuchi, Y., Trinh, L., Reiter, J.F., Alexander, A., Yelon,
D. and Stainier, D.Y.R. (2000). The
zebrafish bonnie and clyde gene
encodes a Mix family homeodomain protein that regulates the generation of
endodermal precursors. Genes & Development 14: 1279-1289.
37.
Yelon,
D., Ticho, B, Halpern, M., Ruvinsky, I., Ho, R., Silver, L.M. and Stainier,
D.Y.R. (2000). The bHLH transcription
factor Hand2 plays parallel roles in zebrafish heart and pectoral fin
development. Development 127:
2573-2582. See Commentary in Nature 406, 953-954.
*38. Kupperman, E., An, S., Osborne, N., Waldron,
S. and Stainier, D.Y.R. (2000). A
sphingosine 1-phosphate receptor regulates cell migration during vertebrate
heart development. Nature 406:
192-195.
See Commentaries in Nature 406, 141-142 and in Science
289, 509.
39. Liao, W., Ho, C.-H., Yan, Y.L.,
Postlethwait, J. and and Stainier, D.Y.R. (2000). Hhex and Scl function in parallel to regulate
early endothelial and blood differentiation in zebrafish. Development
127: 4303-4313.
40.
Motoike,
T., Loughna, S., Perens, E. Roman, B.L., Liao, W., Chau, T.C., Richardson,
C.D., Kawate, T., Kuno, J., Weinstein, B.M, Stainier, D.Y.R. and Sato, T.N.
(2000). Universal GFP Reporter for the Study of Vascular Development. Genesis
28: 75-81.
41.
Reiter,
J.F, Kikuchi, Y. and Stainier, D.Y.R. (2001).
Multiple roles for Gata5 in zebrafish endoderm formation. Development
128: 125-135.
42.
Reiter,
J.F., Verkade, H. and Stainier, D.Y.R. (2001).
Bmp2b and Oep promote early myocardial differentiation through their regulation
of gata5. Developmental Biology 234:
330-338.
43. Kikuchi, Y., Agathon, A., Alexander, J.,
Thisse, C., Waldron, S., Yelon, D., Thisse, B. and Stainier,
D.Y.R.
(2001). casanova encodes a novel Sox-related protein necessary and
sufficient for early endoderm formation in zebrafish. Genes
& Development 15: 1493-1505.
*44. Walsh, E.C. and Stainier, D.Y.R. (2001). UDP-glucose
dehydrogenase required for cardiac valve formation in zebrafish. Science
293: 1670-1673. Highlighted in Faculty of 1000.
45. Horne-Badovinac, S., Lin, D., Waldron, S.,
Schwartz, M. Pawson, A., Jan, Y.N., Stainier, D.Y.R. and Abdelilah-Seyfried, S. (2001). Positional cloning of heart and soul reveals multiple roles for PKCl
in zebrafish organogenesis. Current Biology 11:1492-1502. D.Y.R.S.
senior author.
46. Keegan, B.R., Feldman, J.L., Lee, D.H.,
Koos, D.S., Ho, R.K., Stainier, D.Y.R. and
Yelon D. (2002). The elongation factors Pandora/Spt6 and
Foggy/Spt5 promote transcription in the zebrafish embryo. Development
129: 1623-1632.
47. Sehnert, A., Huq, A., Weinstein, B.,
Fishman, M.C. and Stainier, D.Y.R. (2002).
Cardiac Troponin T plays
essential roles in sarcomere assembly
and cardiac contractility. Nature Genetics 31: 106-110.
48. The Ciona genome consortium (Dehal et al.)
(2002). The draft genome of Ciona intestinalis: insights into
chordate and vertebrate origins. Science 298: 2157-2167.
49. Field, H., Ober, E.A., Roeser, T. and
Stainier, D.Y.R. (2003). Formation of the digestive system in
zebrafish: I. Liver morphogenesis. Developmental Biology 253: 279-290.
50. Miller, C.T., Yelon, D., Stainier, D.Y.R.
and Kimmel, C.B. (2003). Two endothelin1 effectors, Hand2 and Bapx1,
pattern ventral pharyngeal cartilage and the jaw joint. Development
130:1353-1365.
51. Field, H.A., Dong, P.D.S., Beis, D. and
Stainier, D.Y.R. (2003). Formation of the digestive system in
zebrafish: II. Pancreas morphogenesis. Developmental Biology 261: 197-208.
52. Trinh, L.A., Meyer D. and Stainier, D.Y.R. (2003). The Mix family homeodomain gene bonnie and clyde functions with other
components of the Nodal signaling pathway to regulate neural patterning in
zebrafish. Development 130:
4989-4998.
53. Tidyman, W.E., Sehnert, A.J., Huq, A.,
Agard, J., Deegan, F., Stainier, D.Y.R. and Ordahl, C.P. (2003). In vivo regulation of the chicken cardiac
troponin T gene promoter in zebrafish. Dev. Dyn. 227:
484-496.
*54. Horne-Badovinac, S., Rebagliati, M. and
Stainier, D.Y.R. (2003). A cellular framework for gut looping
morphogenesis in zebrafish. Science 302: 662-665. Highlighted in Faculty of 1000.
55. Berdougo, E., Coleman, H., Lee, D.H.,
Stainier, D.Y.R. and Yelon, D.
(2003). Mutation of weak atrium/atrial myosin heavy chain disrupts atrial function and
influences ventricular morphogenesis in zebrafish. Development 130:
6121-6129.
56. Ober, E.A., Olofsson, B., Makinen, T., Jin,
S.-W., Shoji, W., Koh, G.Y., Alitalo, K. and Stainier, D.Y.R. (2004). Vegfc is required for vascular development
and endoderm morphogenesis in zebrafish.
EMBO reports 5: 78-84.
57.
Reim, G., Mizoguchi, T., Stainier, D.Y., Kikuchi, Y. and Brand, M.
(2004). The POU domain protein Spg
(Pou2/Oct4) is essential for endoderm formation in cooperation with the HMG
domain protein Casanova. Dev. Cell 6: 91-101. Highlighted in Faculty of 1000.
58. Trinh, L.A. and Stainier, D.Y.R. (2004). Fibronectin regulates epithelial organization during myocardial
migration
in zebrafish. Dev. Cell 6:
371-382. Highlighted in Faculty of 1000.
59. Parker, L.H., Schmidt, M., Jin, S.-W., Gray, A.M., Beis, D., Pham, T., Frantz, G., Palmieri, S., Hillan, K., Stainier, D.Y.R., de Sauvage, F.J., Ye, W. (2004). A novel endothelial cell derived secreted factor VEMF regulates vascular tube formation. Nature 428: 754-758.
60. Kikuchi, Y., Verkade, H., Reiter, J.F., Kim, C.-H., Chitnis, A.B., Kuroiwa, A. and Stainier, D.Y.R. (2004). Notch signaling can regulate endoderm formation in zebrafish. Dev. Dyn. 229: 756-762.
61. Bartman, T., Walsh, E.C., Wen, K.-K., McKane, M., Ren, J., Alexander, J., Rubenstein, P.A. and Stainier, D.Y.R. (2004). Early Myocardial Function Affects Endocardial Cushion Development in Zebrafish. PLoS Biology 2: 673-681.
62. Trinh, L.A., Yelon, D. and Stainier, D.Y.R. (2005). Hand2 regulates epithelial formation during myocardial differentiation. Current Biology 15: 441-446.
63. Qian, F., Zhen, F., Ong, C., Jin, S.-W., Soo, M.H., Stainier, D.Y.R., Lin, S., Peng, J. and Wen, Z. (2005). Microarray analysis of zebrafish cloche mutant using amplified cDNA and identification of potential downstream target genes. Dev. Dyn. 233: 1163-1172.
64. Bree, R.T., McLoughlin, S., Jin, S.-W., McMeel, O.M., Stainier, D.Y.R., Grealy, M. and Byrnes, L. (2005). nanor, a novel zygotic gene, is expressed initially at the midblastula transition in zebrafish. Biochem. Biophys. Res. Commun. 333: 722-728.
65. Ng, A.N.Y., de Jong-Curtain, T.A., White, S.J., Mawdsley, D.J., Shin, J., Appel, B., Dong P.D.S., Stainier, D.Y.R. and Heath, J.K. (2005). Formation of the digestive system in zebrafish. III. Intestinal epithelium morphogenesis. Developmental Biology 286, 114-135.
66. Beis, D., Bartman, T., Jin, S.-W., Scott,
I.C., D’Amico, L., Ober, E.A., Verkade, H., Frantsve, J., Field,
H.A., Wehman, A., Baier, H., Talafuss,
A., Bally-Cuif, Chen, J.-N., Stainier, D.Y.R. and Jungblut, B.
(2005).
Genetic and cellular analyses of zebrafish atrio-ventricular cushion and
valve development.
Development
132: 4193-4204. D.Y.R.S. senior author.
67. Jin, S.-W, Beis, D., Mitchell, T., Chen,
J.-N. and Stainier, D.Y.R. (2005).
Cellular and molecular analyses of vascular tube and lumen formation in
zebrafish. Development 132: 5199-209.
68. Corbit, K.C., Aanstad, P., Singla, V.,
Norman, A.R., Stainier, D.Y.R. and Reiter, J.F. (2005). Vertebrate
Smoothened functions at the primary
cilium. Nature 437: 1018-1021.
*69. Ober, E.A., Verkade, H., Field, H.A. and
Stainier, D.Y.R. (2006). Mesodermal Wnt2b signaling positively
regulates liver specification. Nature 442: 688-691. Highlighted in
Nature Genetics, Nature Cell Biology,
Faculty of 1000 and Current Biology.
*70. Vogeli, K.M., Jin, S.-W., Martin, G.R. and
Stainier, D.Y.R. (2006). A common progenitor for hematopoietic and
endothelial lineages in the zebrafish gastrula.
Nature 443: 337-339. Highlighted in Faculty of 1000.
71. Sakaguchi, T., Kikuchi, Y., Kuroiwa, A.,
Takeda, H. and Stainier, D.Y.R. (2006). The yolk syncytial layer regulates myocardial
migration by influencing extracellular matrix assembly in zebrafish. Development
133: 4063-4072.
72. Schlegel, A. and Stainier, D.Y.R. (2006). Microsomal triglyceride transfer protein is
required for yolk lipid utilization and absorption of dietary lipids in
zebrafish larvae. Biochemistry 45:
15179-15187.
73. D’Amico, L., Scott, I.C., Jungblut, B. and
Stainier, D.Y.R. (2007). A mutation in zebrafish hgmcr1b reveals a
role for isoprenoids in vertebrate heart tube formation. Current
Biology 17: 252-259.
74. Dong, P.D.S., Munson, C., Norton, W.,
Crosnier, C., Pan, X., Gong, Z., Neumann, C.J. and Stainier, D.Y.R. (2007). Fgf10 regulates hepatopancreatic ductal
system patterning and differentiation. Nature Genetics 39: 397-402.
75. Curado, S.,
Anderson, R.M., Jungblut, B., Mumm, J., Schroeter, E. and Stainier, D.Y.R.
(2007).
Conditional targeted cell ablation in
zebrafish: A new tool for regeneration studies.
Developmental
Dynamics 236: 1025-35.
76. Scott, I.C., Masri, B., D’Amico, L., Jin,
S.-W., Jungblut, B., Wehman, A., Baier, H., Audigier, Y. and Stainier, D.Y.R.
(2007). The G protein-coupled receptor
Agtrl1b regulates early development of myocardial progenitors. Developmental
Cell 12: 403-413. Highlighted in Developmental Cell and Cell.
77. Shin D., Shin C.H., Tucker J., Ober E.A.,
Rentzsch F., Poss K.D., Hammerschmidt M., Mullins M.C. and Stainier D.Y.R.
(2007). Bmp and Fgf
signaling are essential for liver specification in zebrafish. Development 134: 2041-2050.
78. Jin, S.W., Herzog,
W., Santoro, M.M., Mitchell, T.S., Frantsve, J., Jungblut, B., Beis, D., Scott,
I.C., D'Amico, L.A., Ober, E.A., Verkade, H., Field, H.A., Chi, N.C., Wehman,
A.M., Baier, H., and Stainier, D.Y.R. (2007) A transgene-assisted genetic
screen identifies essential regulators of vascular development in vertebrate
embryos. Developmental Biology 307:
29-42.
79. Arnaout, R., Ferrer,
T., Huisken, J., Spitzer, K., Stainier, D.Y.R.†, Tristani-Firouzi, M.†, and Chi, N.C.† (2007)
Zebrafish model for human long QT syndrome. Proc.
Natl. Acad. Sci. USA 104: 11316-11321. †corresponding authors.
*80. Bagnat, M., Cheung,
I.D., Mostov, K.E. and Stainier D.Y.R. (2007). Genetic
control of single lumen formation in the zebrafish gut. Nature
Cell Biology 9: 954-960. Highlighted in Nature Cell Biology,
J, Cell Biology, Faculty of 1000 and Nature Reviews Genetics.
81. Huisken, J. and and Stainier D.Y.R. (2007). Even fluorescence excitation by multi-directional selective plane
illumination microscopy (mSPIM). Optics
Letters 32: 2608-2610.
82. Santoro, M.M.,
Samuel, T., Mitchell, T.S., Reed, J.C. and Stainier D.Y.R. (2007). Birc2/Iap1 regulates endothelial cell integrity and blood vessel
homeostasis. Nature Genetics 39: 1397-1402. Highlighted in Nature Genetics.
83. Scherz,
P.J., Huisken J., Sahai-Hernandez, P. and Stainier D.Y.R. (2008). High
speed imaging of developing heart valves reveals interplay of morphogenesis and
function. Development 135:
1179-1187.
84. Chi, N.C, Shaw R.M., De Val, S., Kang, G., Jan, L.Y., Black B.L.
and Stainier D.Y.R.
(2008). Foxn4 directly
regulates tbx2b expression and
atrioventricular canal formation. Genes
& Development 22: 734-9.
*85. Chi, N.C., Shaw R.M., Jungblut, B., Huisken J., Arnaout, R., Scott, I.C., Beis, D., Ferrer, T.,
Xiao, T., Baier, H., Jan, L.Y., Tristani-Firouzi, M. and
Stainier D.Y.R. (2008). Genetic and physiologic dissection of the
vertebrate cardiac conduction system. PLoS Biology 6: 1006-1019.
*86. Chung, W-S. and Stainier D.Y.R. (2008).
Intra-endodermal interactions are required for pancreatic b-cell
induction. Developmental Cell 14: 582-593. Highlighted in Faculty of 1000.
87. Curado, S., Stainier,
D.Y.R. and Anderson, R.M. (2008). Nitroreductase-mediated
cell/tissue ablation in zebrafish: a spatially and temporally controlled
ablation method with applications in developmental and regeneration studies. Nature
Protocol 3: 948-954. D.Y.R.S.
senior author.
88. Shin C.H., Chung,
W-S., Hong S-K., Ober E.A., Verkade, H.,
Field, H., Huisken, J. and Stainier D.Y.R. (2008). Multiple
roles for Med12 in vertebrate endoderm development. Developmental
Biology, 317:
467-479.
89. Dong, P.D.S., Provost, E.,
90. Bit-Avragim, N.,
Hellwig, N., Rudolph, F., Munson, C., Stainier, D.Y.R., and Abdelilah-Seyfried,
S. (2008). Divergent polarization
mechanisms during vertebrate epithelial development mediated by the Crumbs
complex protein Nagie oko. J. Cell Sci.
121: 2503-2510.
91. Fish, J.E., Santoro,
M.M., Morton, S.U., Yu, S., Yeh, R.F., Wythe, J.D., Ivey, K.N., Bruneau, B.G., Stainier D.Y.R. and Srivastava, D. (2008). miR-126 regulates angiogenic signaling and
vascular integrity. Developmental Cell 15: 271-284.
92. Morton, S.U., Scherz, P.J., Cordes, K.R., Ivey, K.N., Stainier D.Y.R. and Srivastava, D. (2008). microRNA regulation of cardiac patterning. Proc.
Natl. Acad. Sci. USA 105: 17830-5.
93. Sakaguchi, T.F., Sadler, K.C., Crosnier, C.
and Stainier, D.Y.R. (2008). Endothelial signals modulate hepatocyte
apico-basal polarization in zebrafish. Current Biology 18: 1565-1571.
94. De Val, S., Chi,
N.C, Meadows, S.M., Minovitsky, S., Anderson, J., Harris, I.A., Ehlers, M.L.,
Agarwal, P., Visel, A., Xu, S.-M., Pennacchio, L.A., Dubchak, I., Krieg, P.A., Stainier D.Y.R. and Black B.L. (2008). A
Forkhead-Ets transcription factor code for vascular development. Cell 135: 1053-1064. Highlighted in Faculty of 1000.
95. Munson, C., Huisken,
H., Bit-Avragim, N., Kuo, T., Dong, P.D., Ober E.A., Verkade, H., Abdelilah-Seyfried, S. and Stainier, D.Y.R. (2008). Regulation of neurocoel morphogenesis by
Pard6gb. Developmental
Biology 324: 41-54.
96. Chung, W-S.,
Shin, C.H. and Stainier
D.Y.R. (2008). Bmp2 signaling regulates
the hepatic vs pancreatic fate decision.
Developmental Cell 15: 738-748. Highlighted in Faculty of 1000.
*97. Osborne, N., Brand-Arzamendi, K., Ober E.A., Jin, S.W., Verkade, H.,
Holtzman, N.G., Yelon, D. and Stainier, D.Y.R. (2008). The Spinster homologue, Two of hearts, is
required for sphingosine 1-phosphate signaling in zebrafish. Current Biology
18: 1882-1888. Highlighted
in Science.
98. de
Jong-Curtain, T.A., Parslow, A.C., Trotter, A.J., Hall, N.E., Verkade, H.,
Tabone, T., Christie, E.L., Crowhurst, M.O., Layton, J.E., Shepherd, I.T.,
Nixon, S.J., Parton, R.G., Zon, L.I., Stainier, D.Y.R., Lieschke, G.J., Heath,
J.K. (2008). Abnormal Nuclear Pore
Formation Triggers Apoptosis in the Intestinal Epithelium of elys-Deficient
Zebrafish. Gastroenterology 136:
902-911.
99. Aanstad, P., Santos, N., Corbit, K.C., Scherz, P.J., Trinh, L.A., Salvenmoser, W., Huisken, J., Reiter,
J.F. and Stainier, D.Y.R. (2009). The extracellular domain of Smoothened regulates ciliary localisation and is required for high level Hh signaling. Current
Biology 19: 1034-1039.
100. Goll, M.G., Anderson, R.M., Stainier, D.Y.R.,
Spradling, A.C. and Halpern, M.E. (2009).
Transcriptional silencing and reactivation in transgenic zebrafish. Genetics
182: 747-755.
101. Herzog, W., Muller, K., Huisken, J. and Stainier,
D.Y.R. (2009). Genetic evidence for a
noncanonical function of Seryl-tRNA synthetase in vascular development. Circulation
Research, 104: 1260-1266.
102. Santoro, M.M., Pesce, G. and Stainier, D.Y.R.
(2009). Characterization of vascular
mural cells during zebrafish development.
Mech. Dev. 126: 638-649. Highlighted in Faculty of 1000.
103. Anderson, R.M., Bosch, J.A., Goll, M.G., Hesselson,
D., Dong, P.D.S., Shin D., Chi,
N.C., Shin C.H., Schlegel, A., Halpern, M.E. and Stainier, D.Y.R. (2009). Loss of Dnmt1 catalytic activity reveals
multiple roles for DNA methylation during pancreas development and regeneration. Developmental Biology 334: 213-223.
104. Hesselson, D., Anderson, R.M., Beinat, M. and
Stainier, D.Y.R. (2009). Distinct
populations of quiescent and proliferative pancreatic β-cells identified
by HOTcre mediated labeling.
Proc. Natl. Acad. Sci. USA 106: 14896-14901. Highlighted in Faculty of 1000.
105. Lee, C.Y., Vogeli, K.M., Kim, S-H., Chong
S-W., Jiang Y-J., Stainier, D.Y.R. and Jin, S-W. (2009). Notch Signaling Functions as a Cell Fate Switch
Between the Endothelial and the Hematopoietic Lineages. Current Biology 19:
1616-1622.
*106. Herbert, S.P., Huisken, J., Kim, T.N., Feldman,
M.E., Houseman, B.T., Wang, R.A., Shokat, K.M. and Stainier, D.Y.R. (2009). Arterial/Venous Segregation by Selective Cell
Sprouting: An Alternative Mode of Blood Vessel Formation. Science
326: 294-298. Highlighted in Science, Faculty of 1000.
107. Smyth, J.W., Hong, T.-T., Gao, D., Vogan, J.,
Jensen, B.C., Fong, T.S., Simpson, P.C., Stainier, D.Y.R., Chi, N.C. and Shaw,
R.M. (2009). Limited forward
trafficking of Connexin43 reduces cell-cell coupling in stressed
myocardium. J. Clin. Invest. 120:
266-279. Highlighted in Faculty of 1000.
108. Chung, W-S., Andersson, O.,
Row, R., Kimelman, D. and Stainier D.Y.R. (2010). Suppression of Alk8-mediated Bmp signaling cell-autonomously
induces pancreatic β-cells. Proc. Natl. Acad. Sci. USA 107:
1142-1147.
109. Bertrand,
J.Y., Chi, N.C., Santoso, B., Teng, S., Stainier D.Y.R. and Traver D. (2010).
Hematopoietic
stem cells derive directly from aortic endothelium during development. Nature
464: 108-111. Highlighted in Faculty of 1000.
110. Kikuchi, K.,
Holdway, J.E., Werdich, A.A., Anderson, R. M., Fang, Y., Egnaczyk, G.F., Evans,
T., MacRae, C.A., Stainier
D.Y.R. and Poss, K.D.
(2010). Primary contribution to zebrafish heart regeneration
by Gata4+ cardiomyocytes. Nature 464: 601-605. Highlighted
in Circulation Research.
111. Curado, S., Ober,
E.A., Walsh, S.,
Cortes-Hernandez, P., Verkade, H., Koehler, C.M. and Stainier D.Y.R. (2010). The mitochondrial import gene tomm22 is specifically required
for hepatocyte survival and provides a liver regeneration model. Disease
Models and Mechanisms 3,
486-495.
112. Liu, J. and Stainier D.Y.R. (2010).
Tbx5 and Bmp signaling are essential for proepicardium specification in
zebrafish. Circulation
Research 106:1818-1828.
113. Yin, C., Kikuchi, K., Hochgreb, T., Poss, K.D. and Stainier D.Y.R. (2010). Hand2
regulates extracellular matrix remodeling essential for gut-looping
morphogenesis in zebrafish. Developmental Cell
18, 973-984.
114.
Chi,
N.C., Bussen, M., Brand-Arzamendi, K., Ding, C., Olgin, J.E., Shaw R.M.,
Martin, G.R. and Stainier D.Y.R. (2010). Cardiac conduction is required to preserve
cardiac chamber morphology. Proc. Natl. Acad. Sci. USA
107, 14662-14667. Highlighted in Nature.
115. Bagnat, M., Navis, A., Herbstreith, S., Brand-Arzamendi, K., Curado, S., Gabriel, S., Mostov, K.,
Huisken, J and
Stainier D.Y.R. (2010). Cse1l is a negative regulator of
CFTR-dependent fluid secretion.
Current Biology 20, 1840-1845.
116. Liu, J., Bressan,
M., Hassel, D., Huisken, J., Staudt, D., Kikuchi, K., Poss, K.D., Mikawa, T. and
Stainier, D.Y.R. (2010). A
dual role for ErbB2 signaling in cardiac trabeculation. Development
137, 3867-3875.
*117.
Arrenberg, A.B., Stainier, D.Y.R., Baier, H.
and Huisken, J. (2010).
Optogenetic control of cardiac function. Science
330, 971-974. D.Y.R.S.
senior author. Highlighted in Nature.
118. Kalousova, A., Mavropoulos, A., Adams, B.A.,
Nekrep, N., Li, Z., Krauss, S., Stainier, D.Y.R. and
German,
M. (2010). Dachshund homologues
play a conserved role in islet cell development.
Developmental Biology 348, 143-152.
119. Jurczyk, A., Roy, N., Bajwa, R., Gut, P., Lipson, K., Yang, C.,
Covassin, L., Racki, W.J., Rossini,
A.A., Philips, N.,
Stainier, D.Y.R., Grenier, D.L., Brehm, M.A., Borteli, R. and DiIorio, P. (2011).
Dynamic glucoregulation
and mammalian-like responses to metabolic and developmental disruption in
zebrafish. Gen
Comp Endocrinol 170, 334-345.
120. Tittle,
R., Sze, R., Ng, A., Nuckels, R.J., Swartz, M.E., Anderson, R.M., Bosch, J., Stainier, D.Y.R.,
Eberhart, J.K. and Gross, J.M. (2011). Uhrf1 and Dnmt1 are required for development and maintenance of
the zebrafish lens. Developmental
Biology 350, 50-63.
121. Takeuchi,
J.K., Togi, K., Lou, X., Alexander, J., Delgado-Olguin, P., Holloway, A., Mori,
A., Munson, C., Wylie, J., Sukonnik, T., Kaynak, B., Zhu, Y., Yuqing, Z., Yeh,
R., Henkelman, M., Harvey, R., Izumo, S., Metzger, D., Chambon, P., Stainier, D.Y.R.,
Pollard, K., Scott, I.C. and Bruneau, B.G. (2011). Chromatin Remodeling Complex Dosage Modulates
Transcription Factor Function in Cardiogenesis and Congenital Heart Disease. Nature
Communications 2, 187.
122. Shin, D., Lee, Y. Poss, K.D. and Stainier D.Y.R. (2011). Restriction of hepatic competence by Fgf
signaling. Development 138,
1339-1348.
123. Fish,
J.E., Wythe, J.D., Xiao, T., Bruneau, B.G., Stainier D.Y.R., Srivastava, D. and Woo, S. (2011). A Slit/miR-218/Robo regulatory loop is
required during heart tube formation in zebrafish. Development
138, 1409-1419.
124. Delgado-Olguin, P., Brand-Arzamendi, K.,
Scott, I.A., Jungblut, B., Stainier
D.Y.R., Bruneau, B.G. and
Recillas-Targa, F. (2011).
CTCF promotes muscle differentiation by modulating the activity of myogenic
regulatory factors. Journal of Biological Chemistry, in press.
125. Hesselson, D.,
Anderson, R.M. and Stainier, D.Y.R. (20011). Suppression
of Ptf1a activity induces acinar to endocrine conversion. Current Biology, in press.
Review Articles and Book
Chapters
1. Stainier, D.Y.R. and Fishman, M.C. (1993). Cardiac morphogenesis in the zebrafish, patterning the heart tube along the anteroposterior axis. In: Bernfield, M. (ed), Molecular Basis of Morphogenesis, 51 st Annual Symposium of the Society for Developmental Biology, John Wiley & Sons, New York, NY, pp 77-89.
2. Stainier, D.Y.R. and Fishman, M.C. (1994). The zebrafish as a model system to study cardiovascular development. Trends in Cardiovascular Medicine 4: 207-212.
3. Fishman, M.C. and Stainier, D.Y.R. (1994). Cardiovascular development: Prospects for a genetic approach. Circulation Research 74: 757-763.
4. Fishman, M.C., Stainier, D.Y.R.S., Breitbart, R. and Westerfield, M. (1997). Zebrafish: Genetic and embryological methods in a transparent vertebrate embryo. In: Emerson, C.P. and Sweeney, H.L. (eds), Methods in Cell Biology, vol.52, Methods in Muscle Biology, Academic Press, San Diego, CA, pp 67-82.
5. Alexander, J.
and Stainier, D.Y.R. (1999). Mutations
affecting cardiac development in zebrafish.
In Heart Development.: (eds.
6. Parker, L.H., Zon, L. and Stainier, D.Y.R. (1999). Blood and vascular gene expression. In: Detrich, W., Zon, L. and Westerfield, M. (eds), Methods in Cell Biology, The Zebrafish, Academic Press, San Diego, CA, pp 313-336.
7. Yelon, D. and Stainier, D.Y.R. (1999). Patterning during organogenesis: genetic analysis of cardiac chamber formation. Semin. Cell. Dev. Biol. 10: 93-98.
8. Walsh, E. and Stainier, D.Y.R. (2000). Cardiac development in vertebrates. In Genetic models in Cardiorespiratory Biology (eds. Haddad, G.G. and Xu, T.; ex. ed. Lenfant, C.). Marcel Dekker, NY, pp 203-238.
9. Stainier, D.Y.R. (2001). Zebrafish genetics and vertebrate heart formation. Nature Reviews Genetics 2: 39-48.
10. Warga, R.M. and
Stainier, D.Y.R. (2002). The guts of
endoderm formation. In Pattern Formation in Zebrafish (ed.
Solnica-Krezel, L.).
11. Stainier, D.Y.R. (2002). (Traduit par Simone Gilgenkrantz). Contribution du poisson zèbre à l’étude moléculaire du développement du coeur des vertébrés. Médecine/Sciences 18:448-456.
12. Jin, S-K,
Jungblut, B. and Stainier, D.Y.R. (2002). Angiogenesis during zebrafish
development. In Genetics of Angiogenesis, (ed. Jay Hoying). Bios,
13. Yelon, D. and Stainier, D.Y.R. (2002). Pattern formation: swimming in retinoic acid. Current Biology 12: R707-709.
14. Scott, I. and Stainier, D.Y.R. (2002). Fishing out a new heart. Science 298: 2141-2142.
15. Stainier, D.Y.R., Beis, D., Jungblut, B. and Bartman, T. (2002). Endocardial cushion formation in zebrafish. In The Cardiovascular System, proceedings of the 67th CSH Symposium on Quantitative Biology 67: 49-56.
16. Stainier, D.Y.R. (2002). A glimpse into the molecular entrails of endoderm formation. Genes & Development 16: 893-907.
17. Sehnert, A. and Stainier, D.Y.R. (2002). A window to the heart: can zebrafish mutants help us understand heart disease in humans? Trends in Genetics 18: 491-494.
18. Ober, E.A., Field, H.A. and Stainier, D.Y.R. (2003). From endoderm formation to liver and pancreas development in zebrafish. Mechanisms of Development 120: 5-18.
19. Osborne, N. and Stainier, D.Y.R. (2003). Lipid receptors in cardiovascular development. Annual Review in Physiology 65: 23-43.
20. Stainier, D.Y.R. and Pourquie, O. (2003). Entrails, heart, brain, limbs, and lymphatics, a recipe for success? Dev. Cell. 5: 193-196.
21. Scott, I. and Stainier, D.Y.R. (2003). Twisting the body into shape. Nature 425: 461-463.
22. Trinh, L.A. and Stainier, D.Y.R. (2004). Cardiac Development. In: Detrich, W., Zon, L. and Westerfield, M. (eds), Methods in Cell Biology, The Zebrafish, Academic Press, San Diego, CA, pp 455-473.
23. Stainier, D.Y.R. (2005). No organ left behind: Tales of gut development and evolution. Science 307: 1902-1904.
24. Beis, D. and Stainier, D.Y.R. (2005). In vivo cell biology: following the zebrafish trend. Trends in Cell Biology 16: 105-112.
25. Stainier, D.Y.R. (2006). No stem cell is an islet (yet). NEJM 354: 521-523.
26. Curado, S. and Stainier, D.Y.R. (2006). The HeArt of Regeneration. Cell 127: 462-464.
27. Schegel, A. and Stainier, D.Y.R. (2007). Lessons from “lower” organisms: what worms, flies, and zebrafish can teach us about human energy metabolism. PLoS Genetics 3: 2037-2048.
28. Huisken, J. and Stainier, D.Y.R. (2009). Selective plane illumination microscopy techniques in developmental biology. Development 136, 1963-1975.
29. Trinh, L.A. and Stainier, D.Y.R. (2009). Cardiac Development. In “Essential Zebrafish Methods: Cell and Developmental Biology, Academic Press, Philadelphia, PA, pp 479-499.
30. Kawahara,
A. and Stainier, D.Y.R. (2010). Noncanonical activity of Seryl-Transfer RNA
Synthetase and vascular development. Trends
in Cardiovascular Medicine 19,
179-182.
31. Wilson, C.W. and Stainier, D.Y.R. (2010). Vertebrate Hedgehog signaling: cilia
rule. BMC Biology 8,
102-104.
32. Curado, S. and Stainier D.Y.R. (2010). deLiver’in regeneration: injury response and
development.
Seminars in Liver Disease 30, 288-295.
5 SIGNIFICANT REFEREED PUBLICATIONS
Kupperman,
E., An, S., Osborne, N., Waldron, S. and Stainier, D.Y.R. (2000). A sphingosine 1-phosphate receptor regulates
cell migration during vertebrate heart development. Nature
406: 192-195.
Horne-Badovinac,
S., Rebagliati, M. and Stainier, D.Y.R. (2003). A cellular framework for gut looping morphogenesis
in zebrafish. Science 302: 662-665.
Ober, E.A.,
Verkade, H., Field, H.A. and Stainier, D.Y.R. (2006). Mesodermal Wnt2b
signaling positively regulates liver specification. Nature
442: 688-691.
Vogeli, K.M.,
Jin, S.-W., Martin, G.R. and Stainier, D.Y.R. (2006). A common progenitor
for hematopoietic and endothelial lineages in the zebrafish gastrula. Nature
443: 337-339.
Herbert, S.P.,
Huisken, J., Kim, T.N.,
RESEARCH STATEMENT
Our work is concerned with the formation, function and
homeostasis of organs during vertebrate development. We are interested in understanding the
cellular and molecular events that underlie cellular differentiation, tissue
morphogenesis and organ function during the formation of the cardiovascular
system (the heart and the blood vessels) as well as the liver and
pancreas. Our initial approach consists
of screening for mutations that affect these processes in zebrafish, a
vertebrate model system that allows forward genetics as well as embryological
studies. This forward genetic approach
leads to the isolation of genes critical for these processes, and together with
complementary methods allows us to assemble underlying molecular pathways. We also aim to understand how these genes
control the behavior of the cells that form these complex three-dimensional
structures, and the zebrafish allows one to study cell behavior in real time
and in the context of the living embryo.
Ultimately, we would like to reach a systems level understanding of
these processes. And, as the work
progresses, we also hope to contribute to the understanding of how defects in
the processes we are studying lead to human congenital disease or
malformations, or even to predisposition to disease.