TETRAD Journal Club Schedule 2013-2014

Date Faculty/Student Speaker
September 25, 2013 Jonathan Kuhn
  Talk Title:
Survivin' without Survivin: Challenging the Current Model of Kinetochore-Microtubule Attachment Regulation
Journal Article:
Campbell CS, Desai A. Tension sensing by Aurora B kinase is independent of survivin-based centromere localization. Nature. 2013 May 2;497(7447):118-21. doi: 10.1038/nature12057. Epub 2013 Apr 21.
Student Coaches:
David Morgan, Mark Von Zastrow.
September 25, 2013 Hiten Madhani
  Talk Title:
The spliceosome rides again
Journal Article:
Fica, S.M., Tuttle, N., Novak, T., Li, N-S, Lu, J., Koodathingal, P., Dai, Q., Staley, J.P, and PIccirilli, J.A. (2013) Direct evidence that RNA catalyzes nuclear pre-mRNA splicing. Nature in press
October 2, 2013 Todd Nystul
  Talk Title:
The "immortal strand hypothesis" gains a new life
Journal Article:
Chromosome-specific nonrandom sister chromatid segregation during stem-cell division. Swathi Yadlapalli and Yukiko M. Yamashita. Nature, 498, 251–254, 2013-6.
October 2, 2013 Jessica Witchley
  Talk Title:
VP40: rearranging how we think about viral protein multifunctionality
Journal Article:
Structural Rearrangement of Ebola Virus VP40 Begets Multiple Functions in the Virus Life Cycle. Zachary A. Bornholdt, Takeshi Noda, Dafna M. Abelson, Peter Halfmann, Malcolm R. Wood, Yoshihiro Kawaoka, Erica Ollmann Saphire. Cell, , 763-774, 2013-8.
Student Coaches:
JJ Miranda, Jeff Cox.
October 9, 2013 Chuck Seller
  Talk Title:
The shocking story of how plants charge up their defenses against insects.
Journal Article:
GLUTAMATE RECEPTOR-LIKE genes mediate leaf-to-leaf wound signalling. Mousavi SA, Chauvin A, Pascaud F, Kellenberger S, Farmer EE.. Nature, 500, 422-426, 2013-8.
Student Coaches:
Robert Edwards, Joachim Li .
October 16, 2013 Katie Mellman
  Talk Title:
The rich get richer through positive feedback
Journal Article:
Psl trails guide exploration and microcolony formation in Pseudomonas aeruginosa biofilms. Kun Zhao, Boo Shan Tseng, Bernard Beckerman, Fan Jin, Maxsim L. Gibiansky, Joe J. Harrison, Erik Luijten, Matthew R. Parsek & Gerard C. L. Wong. Nature, 497, 388-391, 2013-5.
Student Coaches:
Suzanne Noble, Barbara Panning.
October 23, 2013 Martin McMahon
  Talk Title:
The Curious Case Of PTEN-Long -- A Secreted Version Of A Classical Intracellular Tumor Suppressor
Journal Article:
Hopkins BD, Fine B, Steinbach N, Dendy M, Rapp Z, Shaw J, Pappas K, Yu JS, Hodakoski C, Mense S, Klein J, Pegno S, Sulis ML, Goldstein H, Amendolara B, Lei L, Maurer M, Bruce J, Canoll P, Hibshoosh H, Parsons R. A secreted PTEN phosphatase that enters cells to alter signaling and survival. Science. 2013 Jul 26;341(6144):399-402. doi: 10.1126/science.1234907. Epub 2013 Jun 6.
October 23, 2013 Johnny Rodriguez
  Talk Title:
The Original Biofuel: How ATP Powers the Kinesin Motor
Journal Article:
Structure of a kinesin-tubulin complex and implications for kinesin motility. Beniot Gigant, Weiyi Wang, Birgit Dreier, Qiyang Jiang, Ludovic Pecqueur, Andreas Pluckthun, Chunguang Wang, and Marcel Knossow. Nature Structural and Molecular BIology, 20, 1001-1007, 2013-8.
Student Coaches:
James Frasier, Geeta Narlikar.
October 30, 2013 Rebecca Kim
  Talk Title:
Mechanical Forces and Tissue Morphology
Journal Article:
Differential proliferation rates generate patterns of mechanical tension that orient tissue growth. Yanlan Mao, Alexander L Tournier, Andreas Hoppe, Lennart Kester, Barry J Thompson and Nicolas Tapon. The EMBO Journal, , 1-14, 2013-8.
Student Coaches:
Wallace Marshall, Orion Weiner.
November 6, 2013 Fernando Meza Gutierrez
  Talk Title:
When RNAs Attack!
Journal Article:
Fungal Small RNAs Suppress Plant Immunity by Hijacking Host RNA Interference Pathways. Arne Weiberg, Ming Wang, Feng-Mao Lin, Hongwei Zhao, Zhihong Zhang, Isgouhi Kaloshian, Hsien-Da Huang, Hailing Jin. Science, 342, 118-123 , 2003-10.
Student Coaches:
Barbara Panning, Alexander Johnson.
November 13, 2013 Desiree Stanley
  Talk Title:
If you give a mouse a scorpion...
Journal Article:
Voltage-Gated Sodium Channel in Grasshopper Mice Defends Against Bark Scorpion Toxin. Rowe, Xia, Rowe, Cummins & Zakon. Science, 342, 441-446, 2013-10.
Student Coaches:
Mark van Zastrow, Allan Basbaum.
November 13, 2013 Ron Vale
  Talk Title:
Sex and Singing on a Massive Scale
Journal Article:
Independent divergence of 13- and 17-y life cycles among three periodical cicada lineages. Teiji Sota, Satoshi Yamamoto, John R. Cooley, Kathy B. R. Hill, Chris Simon, and Jin Yoshimura. Proc. Natl. Acad. Sci. U.S.A., 110, 6919–6924, 2013-4.
November 20, 2013 Sandra Torres
  Talk Title:
Self-Destructing Message : NMD in Commissural Axon Guidance
Journal Article:
Regulation of Axon Guidance by Compartmentalized Nonsense-Mediated mRNA Decay. Dilek Colak, Sheng-Jian Ji, Bo T. Porse, Samie R. Jaffrey. Cell, 153, 1252-1265, 2013-6.
Student Coaches:
Hiten Madhani, John Rubenstein.
December 4, 2013 James Fraser
  Talk Title:
Burying the hatchet: Designed enzymes go deep
Journal Article:
Blomberg R, Kries H, Pinkas DM, Mittl PR, Grtter MG, Privett HK, Mayo SL, Hilvert D. Precision is essential for efficient catalysis in an evolved Kemp eliminase. Nature. 2013 Oct 16. doi: 10.1038/nature12623. [Epub ahead of print]
December 4, 2013 Kelly Crotty
  Talk Title:
Taking Out the Trash: How Sleep Drives Detoxification of the Brain.
Journal Article:
Sleep Drives Metabolite Clearance from the Adult Brain . Lulu Xie, Hongyi Kang, Qiwu Xu, Michael J. Chen, Yonghong Liao, Meenakshisundaram Thiyagarajan, John O'Donnell, Daniel J. Christensen, Charles Nicholson, Jeffrey J. Iliff, Takahiro Takano, Rashid Deane, Maiken Nedergaard. Science, 342, 373-377, 2013-10.
Student Coaches:
Su Guo, JJ Miranda.
January 8, 2014 Candace Britton
  Talk Title:
Ringing in the new strand
Journal Article:
Ribonucleotides misincorporated into DNA act as strand-discrimination signals in eukaryotic mismatch repair. Medini Manohar Ghodgaonkar, Federico Lazzaro, Maite Olivera-Pimentel, Mariela Artola-Bora´n, Petr Cejka, Martin A. Reijns, Andrew P. Jackson, Paolo Plevani, Marco Muzi-Falconi, and Josef Jiricny. Molecular Cell, 50, 323-332, 2013-5.
Student Coaches:
Jennifer Fung, Hiten Madhani.
January 15, 2014 Sophie Dumont
  Talk Title:
Spindle size: small droplets and a big step forward
Journal Article:
Two papers: Cytoplasmic Volume Modulates Spindle Size During Embryogenesis + Changes in Cytoplasmic Volume Are Sufficient to Drive Spindle Scaling. Good ... and Fletcher, Heald + Hazel ... and Gatlin. Science, 342, 856-860 and 853-856 (sister papers), 2013-11.
January 15, 2014 Andre Lazar
  Talk Title:
Let there be life: a small molecule induces multicellularity in choanoflagellates
Journal Article:
Alegado RA, Brown LW, Cao S, Dermenjian RK, Zuzow R, Fairclough SR, Clardy J, King N. A bacterial sulfonolipid triggers multicellular development in the closest living relatives of animals. Elife. 2012;1:e00013. doi: 10.7554/eLife.00013. Epub 2012 Oct 15.
Student Coaches:
Jeff Cox, Orion Weiner.
January 22, 2014 Lauren Rodriguez
  Talk Title:
A Blossoming Relationship: How Splice Variants with Opposing Effects Control Flowering
Journal Article:
Temperature-dependent regulation of flowering by antagonistic FLM variants. David Pose, Leonie Verhage, Felix Ott, Levi Yant, Johannes Mathieu, Gerco C. Angenent, Richard G. H. Immink, Markus Schmid. Nature, , 414-417, 2013-11.
Student Coaches:
Hiten Madhani, Dave Toczyski.
January 22, 2014 Noelle LEtoile
  Talk Title:
What does your gut say?
Journal Article:
Hsiao EY, McBride SW, Hsien S, Sharon G, Hyde ER, McCue T, Codelli JA, Chow J, Reisman SE, Petrosino JF, Patterson PH, Mazmanian SK. Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell. 2013 Dec 19;155(7):1451-63. doi: 10.1016/j.cell.2013.11.024. Epub 2013 Dec 5.
January 29, 2014 JD Mclaurin
  Talk Title:
When Life gets you Down, Grab hold of an Actin Filament: How nuclear actin keeps RNA droplets afloat
Journal Article:
A nuclear F-actin scaffold stabilizes ribonucleoprotein droplets against gravity in large cells. Marina Feric and Clifford P. Brangwynne. Nature Cell Biology, , 1253-1259, 2013-10.
Student Coaches:
Jack Taunton, Wallace Marshall.
January 29, 2014 Natalia Jura
  Talk Title:
Logging membrane proteins into actin network
Journal Article:
The WAVE Regulatory Complex Links Diverse Receptors to the Actin Cytoskeleton. Baoyou Chen, Klaus Brinkmann, Zhucheng Chen, Chi W. Pak, Yuxing Liao, Shuoyoung Shi, Lisa Henry, Nick V. Grishin, Sven Bogdan and Michael K. Rosen. Cell, , 195-207, 2014-1.
February 5, 2014 Kelli Benedetti
  Talk Title:
Don't lose your hair over it.
Journal Article:
Nfatc1 orchestrates aging in hair follicle stem cells. Brice E. Keyesa, Jeremy P. Segala, Evan Hellera, Wen-Hui Liena, Chiung-Ying Chang, Xingyi Guoc, Dan S. Oristiana, Deyou Zheng, and Elaine Fuchs. PNAS, 110, E4950-E4959, 2013-12.
Student Coaches:
Todd Nystul, Katja Bruckner.
February 5, 2014 Shawn Douglas
  Talk Title:
DNA nano-tools for multiplexed super-resolution microscopy
Journal Article:
Multiplexed 3D cellular super-resolution imaging with DNA-PAINT and Exchange-PAINT. Ralf Jungmann, Maier S Aveñdano, Johannes B Woehrstein, Mingjie Dai, William M Shih, & Peng Yin. Nature Methods, 11, doi:10.1038/nmeth.2835, 2014-2.
February 12, 2014 Orion Weiner
  Talk Title:
The CheYs to bacterial chemotaxis
Journal Article:
Adaptation at the output of the chemotaxis signalling pathway. Yuan J, Branch RW, Hosu BG, Berg HC.. Nature, 484, 233-6, 2012-4.
February 12, 2014 Joel Hrit
  Talk Title:
Shifting into Reverse to Reverse DNA Damage
Journal Article:
UvrD facilitates DNA repair by pulling RNA polymerase backwards. Vitaly Epshtein, Venu Kamarthapu, Katelyn McGary, Vladimir Svetlov, Beatrix Ueberheide, Sergey Proshkin, Alexander Mironov, and Evgeny Nudler. Nature, 505, 372-377, 2014-1.
Student Coaches:
Carol Gross, Jeff Cox.
February 19, 2014 Barbara Panning
  Talk Title:
Reprogramming on Acid
Journal Article:
Stimulus-triggered fate conversion of somatic cells into pluripotency. Haruko Obokata, Teruhiko Wakayama, Yoshiki Sasai, Koji Kojima, Martin P. Vacanti, Hitoshi Niwa, Masayuki Yamato & Charles A. Vacanti. Nature, 505, 641–647, 2014-1.
February 19, 2014 Grace Peng
  Talk Title:
The kids are alright: a protective pheromone inhibits sexual behavior
Journal Article:
A juvenile mouse pheromone inhibits sexual behaviour through the vomeronasal system. David M. Ferrero, Lisa M. Moeller,Takuya Osakada, Nao Horio,Qian Li, Dheeraj S. Roy, Annika Cichy,Marc Spehr, Kazushige Touhara& Stephen D. Liberles. Nature, 502, 368-371, 2013-10.
Student Coaches:
Robert Edwards, Graeme Davis.
February 26, 2014 Danica Fujimori
  Talk Title:
Tricking Ribosomes into Frameshifting
Journal Article:
Regulation of Gene Expression by Macrolide-Induced Ribosomal Frameshifting. Gupta,P; Kannan, K; Mankin, AS; Vazquez-Laslop, N. Mol Cell, 52, 629-642, 2013-12.
February 26, 2014 Arda Mizrak
  Talk Title:
Tough Choice: Decision Between Motility and Sessility in bacteria
Journal Article:
Memory and modularity in cell-fate decision making.. Norman TM, Lord ND, Paulsson J, Losick R.. Nature, 503(7477), 481-486, 2013-11.
Student Coaches:
Carol Gross, Wallace Marshall.
March 5, 2014 Joselyn Del Cid
  Talk Title:
Just Move With It: A Novel Embryonic Signal Promotes Cell Migration in Zebra Fish
Journal Article:
Toddler: An Embryonic Signal That Promotes Cell Movement via Apelin Receptors . Andrea Pauli, Megan L. Norris, Eivind Valen, Guo-Liang Chew, James A. Gagnon, Steven Zimmerman, Andrew Mitchell, Jiao Ma, Julien Dubrelle, Deepak Reyon, Shengdar Q. Tsai, Keith Joung, Alan Saghatelian, Alexander F. Schier . Science, 343, 1248636, 2014-2.
Student Coaches:
Daniel Hart, Dave Toczyski.
March 5, 2014 Kaveh Ashrafi
  Talk Title:
These genes are not the only thing that make me look fat
Journal Article:
Transgenerational inheritance of increased fat depot size, stem cell reprogramming, and hepatic steatosis elicited by prenatal exposure to the obesogen tributyltin in mice.. Chamorro-García R, Sahu M, Abbey RJ, Laude J, Pham N, Blumberg B.. Environ Health Perspect., 121(3), 359-66, 2013-3.
March 12, 2014 Mable Lam
  Talk Title:
The Fats in Your Furrow
Journal Article:
Dividing Cells Regulate Their Lipid Composition and Localization. G. Ekin Atilla-Gokcumen, Eleonora Muro, Josep Relat-Goberna, Sofia Sasse, Anne Bedigian, Margaret L. Coughlin, Sergi Garcia-Manyes, and Ulrike S. Eggert. Cell, , 428-439, 2014-1.
Student Coaches:
Mark Von Zastrow, Sophie Dumont.
March 12, 2014 Miguel Ramalho-Santos
  Talk Title:
(g)rrrrrrRNA gets sexy: ribosomal RNA regulates germline stem cells
Journal Article:
Zhang Q, Shalaby NA, Buszczak M. Changes in rRNA transcription influence proliferation and cell fate within a stem cell lineage. Science. 2014 Jan 17;343(6168):298-301. doi: 10.1126/science.1246384.