UCSF Department of Biochemistry & Biophysics

Geeta Narlikar Elected to the NAS Academy!

Narlikar, a professor of biochemistry and biophysics, studies how the folding and compartmentalization of our genome is controlled to generate the many cell types that make up our body. Her laboratory has made pioneering discoveries about the mechanisms of macromolecules that regulate genome organization. For example, they found that the smallest unit of genome folding, a nucleosome, acts akin to a dynamic receptor rather than a static packaging unit, and that specialized genome folding proteins can keep large chunks of the genome off limits by curling DNA strands into tiny droplets. These types of findings from the Narlikar laboratory are changing textbook descriptions of genome packaging and suggesting new avenues to tackle diseases caused by defects in genome organization.

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