UCSF Department of Biochemistry & Biophysics

Bob Fletterick, PhD


Dr. Robert Fletterick, a Professor in the Department of Biophysics & Biochemistry, and Cellular & Molecular Pharmacology at University of California, San Francisco, is internationally recognized for structural and functional studies on kinesins, phosphorylases and nuclear receptors. Several transcription factors, pluripotency reprogramming factors and nuclear receptors, including SF-1 and LRH-1 are actively studied by X-ray crystallography. A direct path to learn more about the function of LRH-1 employs chemical biology. The idea is to use tethering chemistry, a fixed-point build-out chemistry with Pam England in the Department of Pharmaceutical chemistry. Bio-layer interferometry reveals effects of new chemical probes. Compounds that affect nerve growth factor Nurr1 are sought analogously using a new four component biosensor assay of compound, Nurr1, RXR, and DNA response elements. Dr. Fletterick is a member of the National Academy of Sciences.

UCSF Profiles Page for Bob Fletterick, PhD
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