Alan Frankel, PhD
Dr. Alan Frankel, a Professor in the Department of Biochemistry and Biophysics at the University of California, San Francisco, is interested in understanding the molecular details of sequence-specific recognition, how multiprotein complexes are assembled on RNAs, and in designing novel RNA-binding proteins. The Frankel lab use biochemistry, structural methods, proteomics, and virology to investigate two essential regulatory complexes in HIV: the viral Tat protein and its interactions with the host transcription machinery, and the viral Rev protein and its interactions with host nuclear export complexes. In concert with proteomic studies of HIV-human protein complexes, their studies have led to an understanding of how the virus has evolved adaptable protein interfaces to hijack these two host machines and establish a unique regulatory circuit that drives gene expression during the HIV life cycle. UCSF Profiles Page for Alan Frankel, PhDBack to the top...